KPNA7 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 18258596)
60

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		KPNA7	H1-2
Description		karyopherin subunit alpha 7	H1.2 linker histone, cluster member
Image		No pdb structure
GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Spindle Cytosol NLS-dependent Protein Nuclear Import Complex	Chromatin Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity
	Biological Process	Blastocyst Development Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Transport Epigenetic Regulation Of Gene Expression	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908) Lack of premeditation ( 30718321) Ulcerative colitis ( 20228798 28067908) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		2 interacting genes: H1-2 TWIST1	31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12
Entrez ID		402569	3006
HPRD ID		19598	07514
Ensembl ID		ENSG00000185467	ENSG00000187837
Uniprot IDs		A9QM74	P16403
PDB IDs			8H0V 8H0W 8KE0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Metabolic Process Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Proliferation Involved In Heart Valve Development Embryonic Camera-type Eye Formation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Histone H3K27me3 Reader Activity Regulation Of DNA Metabolic Process Facultative Heterochromatin Formation Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cranial Suture Morphogenesis Negative Regulation Of Macrophage Cytokine Production Eyelid Development In Camera-type Eye Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Cardiac Neural Crest Cell Development Involved In Heart Development Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Mitral Valve Morphogenesis Regulation Of Fatty Acid Beta-oxidation DNA-binding Transcription Repressor Activity Craniofacial Suture Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Migration Involved In Heart Development Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Catabolic Process Neural Crest Cell Development Embryonic Hindlimb Morphogenesis Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of MiRNA Transcription BHLH Transcription Factor Binding Negative Regulation Of Cellular Senescence Chromosome Condensation Negative Regulation Of Gene Expression Chromatin Embryonic Cranial Skeleton Morphogenesis Stem Cell Development Aortic Valve Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Macrophage Cytokine Production Positive Regulation Of Fatty Acid Metabolic Process Hindlimb Morphogenesis	Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II
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