KPNA7

Description		karyopherin subunit alpha 7
Image		No pdb structure
GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Spindle Cytosol NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Blastocyst Development Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Transport Epigenetic Regulation Of Gene Expression
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908) Lack of premeditation ( 30718321) Ulcerative colitis ( 20228798 28067908) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		2 interacting genes: H1-2 TWIST1
Entrez ID		402569
HPRD ID		19598
Ensembl ID		ENSG00000185467
Uniprot IDs		A9QM74
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Metabolic Process Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Proliferation Involved In Heart Valve Development Embryonic Camera-type Eye Formation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Negative Regulation Of Skeletal Muscle Tissue Development Histone H3K27me3 Reader Activity Regulation Of DNA Metabolic Process Facultative Heterochromatin Formation Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cranial Suture Morphogenesis Negative Regulation Of Macrophage Cytokine Production Eyelid Development In Camera-type Eye Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Cardiac Neural Crest Cell Development Involved In Heart Development Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Fatty Acid Beta-oxidation Outer Ear Morphogenesis Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Mitral Valve Morphogenesis Regulation Of Fatty Acid Beta-oxidation DNA-binding Transcription Repressor Activity Craniofacial Suture Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Migration Involved In Heart Development Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Catabolic Process Neural Crest Cell Development Embryonic Hindlimb Morphogenesis Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of MiRNA Transcription BHLH Transcription Factor Binding Negative Regulation Of Cellular Senescence Chromosome Condensation Negative Regulation Of Gene Expression Chromatin Embryonic Cranial Skeleton Morphogenesis Stem Cell Development Aortic Valve Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Macrophage Cytokine Production Positive Regulation Of Fatty Acid Metabolic Process Hindlimb Morphogenesis
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