VWC2L and CD36

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		VWC2L	CD36
Description		von Willebrand factor C domain containing 2 like	CD36 molecule (CD36 blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space AMPA Glutamate Receptor Complex Synapse	Extracellular Space Golgi Apparatus Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Apical Part Of Cell Phagocytic Vesicle Cell Periphery
	Molecular Function	Protein Binding	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Short-chain Fatty Acid Transmembrane Transporter Activity Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Cargo Receptor Activity Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Immune Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity Oleate Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Positive Regulation Of Cell-matrix Adhesion Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Fatty Acid Transport Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Across Plasma Membrane Short-chain Fatty Acid Transport Negative Regulation Of Angiogenesis Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Cellular Response To Oxidative Stress Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Long-chain Fatty Acid Import Into Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Lipid Transport Across Blood-brain Barrier Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Degraded stimulus continuous performance test score ( 31596458) Dietary fat liking ( 32516399) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) PR interval ( 23534349)	Aspartate aminotransferase levels ( 33339817 29403010) Basophil count ( 32888494) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29403010 33339817) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Night sleep phenotypes ( 27126917) Platelet count ( 32888494 33545615 29403010 27863252 22423221) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 28957414 32888494) Response to fenofibrate ( 22890011)
Interacting Genes		29 interacting genes: C17orf50 C22orf39 CD36 CEMP1 CRCT1 CXCL5 CYSRT1 DEFB112 FBXO34 FHL3 HOXA1 KRTAP10-8 KRTAP11-1 KRTAP19-2 LCE1A LCE1C LCE3A LCE3D LCE5A MEOX2 NR4A3 OTX1 PPARA RIPK4 SPATA3 TRIM42 TYRO3 YPEL3 ZNF20	23 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LY6H LYN MATK NRN1 SCRG1 SRC THBS1 VLDLR VWC2L YES1
Entrez ID		402117	948
HPRD ID		19160	01430
Ensembl ID		ENSG00000174453	ENSG00000135218
Uniprot IDs		B2RUY7 B7ZW27	A4D1B1 B7Z6C3 E9PLT1 P16671
PDB IDs			5LGD
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Tissue Development	Developmental Process Integrin Binding Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Non-membrane Spanning Protein Tyrosine Kinase Activity Anatomical Structure Morphogenesis Protease Binding Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Integrin Complex Ephrin Receptor Binding Cellular Response To Growth Factor Stimulus Fibrinogen Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Activator Activity Fc-gamma Receptor Signaling Pathway Response To Growth Factor Cellular Response To Lipoprotein Particle Stimulus Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process System Development T Cell Costimulation Cell Motility Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Skin Morphogenesis Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Low-density Lipoprotein Particle Cellular Response To Oxygen-containing Compound Extracellular Space Focal Adhesion Cell Surface Regulation Of Cell Activation Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Mononuclear Cell Migration Cellular Response To Transforming Growth Factor Beta Stimulus Platelet Alpha Granule Membrane Collagen Type I Trimer
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