VWC2L and LCE3D

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		VWC2L	LCE3D
Description		von Willebrand factor C domain containing 2 like	late cornified envelope 3D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space AMPA Glutamate Receptor Complex Synapse	Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation	Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Degraded stimulus continuous performance test score ( 31596458) Dietary fat liking ( 32516399) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) PR interval ( 23534349)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Psoriasis ( 19169255 20953190 23143594 25854761)
Interacting Genes		29 interacting genes: C17orf50 C22orf39 CD36 CEMP1 CRCT1 CXCL5 CYSRT1 DEFB112 FBXO34 FHL3 HOXA1 KRTAP10-8 KRTAP11-1 KRTAP19-2 LCE1A LCE1C LCE3A LCE3D LCE5A MEOX2 NR4A3 OTX1 PPARA RIPK4 SPATA3 TRIM42 TYRO3 YPEL3 ZNF20	69 interacting genes: ADAMTSL4 ALPP CCN3 CHIC2 CYP21A2 CYSRT1 EFEMP1 EFEMP2 FBLN2 HOXA1 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2A LCE2B LCE2C LCE2D MACO1 MDFI NBPF19 NOTCH2NLA PCSK5 RGS17 RGS20 SDC3 SPRY1 SPRY3 SRPK1 SRPK2 TENM4 TGFB1 TRIM42 TSPAN4 VWC2 VWC2L
Entrez ID		402117	84648
HPRD ID		19160	17263
Ensembl ID		ENSG00000174453	ENSG00000163202
Uniprot IDs		B2RUY7 B7ZW27	Q9BYE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Tissue Development	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Cytosol Keratinization Protein Binding Extracellular Matrix Interstitial Matrix
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