LOXL1 and ELN

Number of citations of the paper that reports this interaction (PMID 16251195)
31

Data Source:
HPRD (two hybrid, in vitro)

		LOXL1	ELN
Gene Name		lysyl oxidase-like 1	elastin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber
	Molecular Function	Copper Ion Binding Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Protein Deamination Extracellular Matrix Organization Response To Lipopolysaccharide Aorta Development Oxidation-reduction Process	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Collagen formation Crosslinking of collagen fibrils Elastic fibre formation Assembly of collagen fibrils and other multimeric structures	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs			Rofecoxib
Diseases
GWAS		Aortic root size ( 19584346) Glaucoma (exfoliation) ( 17690259) Height ( 23563607)
Protein-Protein Interactions		3 interactors: ATXN1 ELN FBLN5	21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1
Entrez ID		4016	2006
HPRD ID		08861	00556
Ensembl ID		ENSG00000129038	ENSG00000049540
Uniprot IDs		Q08397	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Elastic Fiber Assembly Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Removal Of Superoxide Radicals Stress Fiber Assembly Extracellular Matrix Assembly Protein Localization To Cell Surface	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus
Tagcloud ?		addressed anterior aqueous capsule cornea deposited elastic elucidation exfoliation extensively fibers fibrillar glaucoma humor immersed intraocular ipe iris lens material meshwork pigment pseudoexfoliation reaches scarce trabecular ultrastructural underneath xfm	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		addressed anterior aqueous capsule cornea deposited elucidation exfoliation extensively fibrillar glaucoma humor immersed intraocular ipe iris lens material meshwork pigment pseudoexfoliation reaches scarce trabecular ultrastructural underneath xfm	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastin enhance extract fbn1 fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?		elastic fibers