PI3 and CELA1

Number of citations of the paper that reports this interaction (PMID 8794736)
23

Data Source:
HPRD (in vivo)

		PI3	CELA1
Gene Name		peptidase inhibitor 3, skin-derived	chymotrypsin-like elastase family, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Metal Ion Binding
	Biological Process	Copulation Negative Regulation Of Endopeptidase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Pancreas Morphogenesis
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: CELA1 CSTA EVPL KRT1 LOR	6 interactors: A2M CSN2 LPA PI3 SERPINA1 SERPINA3
Entrez ID		5266	1990
HPRD ID		15947	00553
Ensembl ID		ENSG00000124102	ENSG00000139610
Uniprot IDs		P19957	Q9UNI1
PDB IDs		1FLE 2REL
Enriched GO Terms of Interacting Partners?		Skin Development Peptide Cross-linking Keratinocyte Differentiation Epidermal Cell Differentiation Epidermis Development Organ Development Keratinization Epithelial Cell Differentiation System Development Multicellular Organismal Development Anatomical Structure Development Developmental Process Protein Metabolic Process Epithelium Development Pancreas Morphogenesis Complement Activation, Lectin Pathway Exocrine Pancreas Development Tissue Development Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Fibrinolysis	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Acute-phase Response Platelet Degranulation Acute Inflammatory Response Response To Methanol Regulation Of Body Fluid Levels Secretion Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Platelet Activation Regulation Of Metabolic Process Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Cullin Deneddylation Protein Deneddylation Exocytosis Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Complement Activation Inflammatory Response Blood Coagulation Hemostasis Epithelial Structure Maintenance Copulation Secretion By Cell Response To Lead Ion Regulation Of Complement Activation Wound Healing Negative Regulation Of Innate Immune Response Cell Activation Response To Wounding Regulation Of Humoral Immune Response Mating
Tagcloud ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?		antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?