MCCD1 and USP20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCCD1	USP20
Description		mitochondrial coiled-coil domain 1	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process		Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Asthma ( 29273806 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cervical cancer ( 28806749) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Malaria ( 31844061) Ulcerative colitis ( 28067908)	Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: BEX3 BFSP2 CAB39 COX5B FNDC3B KANK2 KRT26 KYNU LMO4 LSM1 MEIS2 MGAT5B MKRN3 MX1 MYL7 P4HA3 PIH1D2 PPP1R16A PRR35 QARS1 RIPPLY1 USHBP1 USP20 ZNF417 ZNF587 ZNF765	71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB
Entrez ID		401250	10868
HPRD ID		17470	07505
Ensembl ID		ENSG00000204511	ENSG00000136878
Uniprot IDs		A0A1U9X802 P59942	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?			Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death
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