ASIC2 and STOM

Number of citations of the paper that reports this interaction (PMID 15471860)
26

Data Source:
HPRD (in vivo)

		ASIC2	STOM
Gene Name		acid sensing (proton gated) ion channel 2	stomatin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine Synapse	Extracellular Space Cytoplasm Cytoskeleton Integral Component Of Plasma Membrane Membrane Vesicle Melanosome Membrane Raft Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity	Protein Homodimerization Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Regulation Of Gene Expression Monovalent Inorganic Cation Transport Regulation Of Vasoconstriction Regulation Of Blood Coagulation Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Transmembrane Transport Cellular Response To Acid Chemical Cellular Response To Acidic PH Positive Regulation Of Cation Channel Activity	Protein Homooligomerization Regulation Of Acid-sensing Ion Channel Activity
Pathways		Ion channel transport Stimuli-sensing channels
Drugs		Amiloride
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ASIC1 ASIC3 PICK1 STOM	9 interactors: ASIC1 ASIC2 ASIC3 DVL3 LANCL1 RPL13A RUVBL1 RUVBL2 SLC2A1
Entrez ID		40	2040
HPRD ID		03471	00585
Ensembl ID		ENSG00000108684	ENSG00000148175
Uniprot IDs		Q16515	P27105
PDB IDs
Enriched GO Terms of Interacting Partners?		Sensory Perception Of Sour Taste Response To PH Sensory Perception Of Taste Enterobactin Transport Regulation Of Acid-sensing Ion Channel Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Siderophore Transport Sodium Ion Transport Protein Homooligomerization DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Sensory Perception Of Chemical Stimulus Neuronal Ion Channel Clustering Protein Oligomerization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Cellular Response To PH Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Long Term Synaptic Depression Response To Acidic PH Protein Homotrimerization Positive Regulation Of Receptor Internalization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Monovalent Inorganic Cation Transport Detection Of Temperature Stimulus Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Protein Trimerization Regulation Of Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Sensory Perception Metal Ion Transport Detection Of Mechanical Stimulus Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cation Transmembrane Transport Receptor Clustering DNA Methylation	Sensory Perception Of Sour Taste Response To PH Sensory Perception Of Taste Cellular Response To Stimulus Histone H2A Acetylation Cellular Response To PH Response To Acidic PH Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Response To Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Sodium Ion Transport Detection Of Mechanical Stimulus Histone H4 Acetylation DNA Duplex Unwinding DNA Geometric Change Enterobactin Transport Negative Regulation Of Formation Of Translation Preinitiation Complex Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Sensory Perception Of Chemical Stimulus Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Siderophore Transport Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Protein Acetylation Dehydroascorbic Acid Transport Monovalent Inorganic Cation Transport Non-canonical Wnt Signaling Pathway Via JNK Cascade Detection Of Abiotic Stimulus Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Process Chromatin Remodeling Xenobiotic Transport Non-canonical Wnt Signaling Pathway Via MAPK Cascade Establishment Of Protein Localization To Chromatin Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Transmembrane Transport Sensory Perception Ion Transport Cellular Response To Acidic PH Negative Regulation Of Receptor Binding Response To Mechanical Stimulus Metal Ion Transport DNA Recombination Peptidyl-lysine Modification Cation Transmembrane Transport
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