ASIC2

Gene Name		acid sensing (proton gated) ion channel 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine Synapse
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Regulation Of Gene Expression Monovalent Inorganic Cation Transport Regulation Of Vasoconstriction Regulation Of Blood Coagulation Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Transmembrane Transport Cellular Response To Acid Chemical Cellular Response To Acidic PH Positive Regulation Of Cation Channel Activity
Pathways		Ion channel transport Stimuli-sensing channels
Drugs		Amiloride
Diseases
GWAS
Protein-protein Interactions		4 interactors: ASIC1 ASIC3 PICK1 STOM
Entrez ID		40
HPRD ID		03471
Ensembl ID		ENSG00000108684
Uniprot IDs		Q16515
PDB IDs
Enriched GO Terms of Interacting Partners?		Sensory Perception Of Sour Taste Response To PH Sensory Perception Of Taste Enterobactin Transport Regulation Of Acid-sensing Ion Channel Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Siderophore Transport Sodium Ion Transport Protein Homooligomerization DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Sensory Perception Of Chemical Stimulus Neuronal Ion Channel Clustering Protein Oligomerization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Cellular Response To PH Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Long Term Synaptic Depression Response To Acidic PH Protein Homotrimerization Positive Regulation Of Receptor Internalization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Monovalent Inorganic Cation Transport Detection Of Temperature Stimulus Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Protein Trimerization Regulation Of Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Sensory Perception Metal Ion Transport Detection Of Mechanical Stimulus Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cation Transmembrane Transport Receptor Clustering DNA Methylation
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