ASIC2

Description		acid sensing ion channel subunit 2
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Density Membrane
	Molecular Function	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Synapse Assembly Phototransduction Sensory Perception Of Sound Response To Mechanical Stimulus Response To Acidic PH Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Positive Regulation Of Synapse Assembly Cellular Response To Xenobiotic Stimulus Cellular Response To Acidic PH Regulation Of Postsynapse Assembly
Pathways		Stimuli-sensing channels
Drugs		Amiloride
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Autism ( 30675382) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Congenital heart disease (septal defects) ( 33201861) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Novel Interacting Genes		1 novel interacting genes: SMG6
Interacting Genes		4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		40
HPRD ID		03471
Ensembl ID		ENSG00000108684
Uniprot IDs		Q16515
PDB IDs		6L6P
Enriched GO Terms of Interacting Partners?		PH-gated Monoatomic Ion Channel Activity Sensory Perception Of Sour Taste Ligand-gated Sodium Channel Activity Response To Acidic PH Sensory Perception Of Taste Sodium Channel Activity Monoatomic Cation Channel Activity Response To PH Establishment Of Localization In Cell Enterobactin Transport Enterobactin Transmembrane Transporter Activity Sensory Perception Of Chemical Stimulus Sodium Ion Transmembrane Transport Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity Siderophore Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Sodium Ion Transport Membrane Curvature Sensor Activity Plasma Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Neurotransmitter Secretion Inorganic Cation Transmembrane Transporter Activity Negative Regulation Of Actin Nucleation Negative Regulation Of Telomere Capping Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Neuronal Ion Channel Clustering Dendritic Spine Maintenance Ion Channel Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Arp2/3 Complex Binding Regulation Of Telomere Capping Long-term Synaptic Depression Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Sensory Perception Regulation Of Transport Cellular Response To PH Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Targeting To Membrane RNA Polymerase Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Exon-exon Junction Complex Telomerase RNA Binding Telomeric DNA Binding
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