ASIC2 and ASIC3

Number of citations of the paper that reports this interaction (PMID 10842183)
31

Data Source:
HPRD (in vivo)

		ASIC2	ASIC3
Gene Name		acid sensing (proton gated) ion channel 2	acid sensing (proton gated) ion channel 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity	Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity PDZ Domain Binding Enterobactin Transporter Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Regulation Of Gene Expression Monovalent Inorganic Cation Transport Regulation Of Vasoconstriction Regulation Of Blood Coagulation Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Transmembrane Transport Cellular Response To Acid Chemical Cellular Response To Acidic PH Positive Regulation Of Cation Channel Activity	Transport Signal Transduction Sensory Perception Response To Heat Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Transmembrane Transport Cation Transmembrane Transport
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs		Amiloride
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ASIC1 ASIC3 PICK1 STOM	9 interactors: ASIC2 CSNK2A1 DLG4 GOPC INADL LIN7B MAGI1 PRKACA STOM
Entrez ID		40	9311
HPRD ID		03471	10626
Ensembl ID		ENSG00000108684	ENSG00000213199
Uniprot IDs		Q16515	Q9UHC3
PDB IDs
Enriched GO Terms of Interacting Partners?		Sensory Perception Of Sour Taste Response To PH Sensory Perception Of Taste Enterobactin Transport Regulation Of Acid-sensing Ion Channel Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Siderophore Transport Sodium Ion Transport Protein Homooligomerization DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Sensory Perception Of Chemical Stimulus Neuronal Ion Channel Clustering Protein Oligomerization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation Cellular Response To PH Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Long Term Synaptic Depression Response To Acidic PH Protein Homotrimerization Positive Regulation Of Receptor Internalization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Monovalent Inorganic Cation Transport Detection Of Temperature Stimulus Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Protein Trimerization Regulation Of Sodium Ion Transmembrane Transport Detection Of Mechanical Stimulus Involved In Sensory Perception Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Sensory Perception Metal Ion Transport Detection Of Mechanical Stimulus Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cation Transmembrane Transport Receptor Clustering DNA Methylation	Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Maintenance Of Apical/basal Cell Polarity Regulation Of Cation Channel Activity Maintenance Of Cell Polarity Regulation Of Ion Transmembrane Transport Cellular Component Assembly Protein Localization To Synapse Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Golgi To Plasma Membrane Transport Cell-cell Signaling Regulation Of Sodium Ion Transport Regulation Of Cellular Component Organization Negative Regulation Of Transport Protein Complex Assembly Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Positive Regulation Of Dense Core Granule Biogenesis Cytoplasmic Sequestering Of CFTR Protein Regulation Of Acid-sensing Ion Channel Activity Post-Golgi Vesicle-mediated Transport Phototransduction Regulation Of Blood Coagulation Detection Of Light Stimulus Histone H3-T6 Phosphorylation Cell-cell Junction Assembly Nucleus Organization Signaling Regulation Of Wound Healing Cell Communication Synaptic Transmission Chemotaxis Spermatid Development Spermatid Differentiation Negative Regulation Of MAPK Cascade Protein Localization To Basolateral Plasma Membrane Sensory Perception Of Sour Taste Detection Of Abiotic Stimulus Cytosolic Calcium Ion Homeostasis Establishment Or Maintenance Of Cell Polarity Regulation Of Behavior Positive Regulation Of Transport Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Grooming Behavior Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ion Transport
Tagcloud ?			amiloride asic1 asic1a asic2a asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Difference) ?			amiloride asic1 asic1a asic2a asics blocker currents cyclooxygenase defense elusive exact existed existence glia homomeric lipopolysaccharide meanwhile microglia microglial neuroinflammatory nonspecific participate pctx1 qpcr scavenger scrape sensing transcriptase
Tagcloud (Intersection) ?