CCDC187 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC187	PLEKHG4
Description		coiled-coil domain containing 187	pleckstrin homology and RhoGEF domain containing G4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Microtubule Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Microtubule Anchoring	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHOC GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		72 interacting genes: ACTN2 ANKRD28 AP2B1 ASB15 BICD2 CARD10 CBY2 CCDC102B CCDC136 CCNDBP1 CDR2 CDR2L CEP63 CEP70 COG6 CRACR2B CSNK2B CYSRT1 DDX17 DEUP1 EFS FRYL FSD2 FXR1 GOLGA2 GOLGA6A GOLGA6L9 GRIPAP1 HMBOX1 HNRNPK HOMER3 HOMEZ HOOK2 HSF2BP IKZF3 INSC KHDRBS3 KIFC3 KRT15 KRT27 KRT31 KRT32 KRTAP6-1 LZTS1 LZTS2 MAGEA6 MCC MDFI MID2 MKRN3 MSS51 MTUS2 NAB2 NCKIPSD PICK1 PLEKHG4 PNMA1 PNMA3 PRKAR1B RINT1 SORBS3 SSX2IP TFIP11 TRAF1 TRAF2 TRIM27 TRIM54 TRIP6 USHBP1 VIM VPS52 ZRANB1	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		399693	25894
HPRD ID		14668	10890
Ensembl ID		ENSG00000260220	ENSG00000196155
Uniprot IDs		A0A096LP49 A0A1W2PQX5	A0A024R6X4 Q58EX7
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Binding Identical Protein Binding Cytoskeleton Intermediate Filament Intermediate Filament Organization Organelle Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Structural Constituent Of Skin Epidermis De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Cytosol Microtubule Organizing Center Organization Microtubule	Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation
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