CDYL2 and SPANXN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDYL2	SPANXN2
Description		chromodomain Y like 2	SPANX family member N2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Histone H3K27me3 Reader Activity Histone H3K9me2/3 Reader Activity	Protein Binding
	Biological Process	Chromatin Organization Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729 29059683) Inflammatory bowel disease ( 27569725) Interleukin-10 levels ( 22205395) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Prostate cancer ( 31748686) Pulse pressure ( 30224653) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		11 interacting genes: DVL3 H3-4 H3C1 HINFP HSF2BP LIG1 LMO3 NXF1 PRMT5 SPANXN2 ZBTB9	50 interacting genes: ANKRD1 ANKRD11 BANP BEND7 BIVM CDC14B CDCA8 CDYL2 COIL DPPA4 EPB41L3 FAM193B FAM204A GPRASP3 H2BC11 H2BC15 H2BC21 KHDC4 KRCC1 L3MBTL3 MEOX2 MTIF3 NOL12 NUMB PBX4 PICK1 RPL27 RRP1 SFMBT1 SMN1 SMN2 SNIP1 SNRPD2 SP3 SP4 SRP14 STAC3 SYTL4 THAP1 TNNI1 VAX1 YAF2 ZBTB48 ZNF19 ZNF2 ZNF438 ZNF526 ZNF655 ZNF75A ZNF84
Entrez ID		124359	494119
HPRD ID		10819	18091
Ensembl ID		ENSG00000166446	ENSG00000268988
Uniprot IDs		Q8N8U2	Q5MJ10
PDB IDs		2MJ8 4HAE 5JJZ 6V2D 6V2H 6V3N 6V8W 8SP6
Enriched GO Terms of Interacting Partners?		Okazaki Fragment Processing Involved In Mitotic DNA Replication Nucleobase-containing Compound Biosynthetic Process DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing Macromolecule Biosynthetic Process DNA Ligase Activity Chromosome Protein Heterodimerization Activity Structural Constituent Of Chromatin Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nucleosome Assembly Nucleosome Nucleosome Organization Spermatogonial Cell Division Histone H4R3 Methyltransferase Activity Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation	Nucleus DNA Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly SMN-Sm Protein Complex Nucleoplasm Protein-RNA Complex Assembly Zinc Ion Binding Sequence-specific DNA Binding SMN Complex Gemini Of Cajal Bodies Protein Binding
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