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HPGDS and MFI2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
HPGDS
MFI2
Gene Name
hematopoietic prostaglandin D synthase
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Integral Component Of Plasma Membrane
Cell Surface
Anchored Component Of Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Magnesium Ion Binding
Glutathione Transferase Activity
Prostaglandin-D Synthase Activity
Calcium Ion Binding
Protein Homodimerization Activity
Iron Ion Binding
Protein Binding
Ferric Iron Binding
Biological Process
Prostaglandin Metabolic Process
Xenobiotic Metabolic Process
Signal Transduction
Locomotory Behavior
Arachidonic Acid Metabolic Process
Cyclooxygenase Pathway
Small Molecule Metabolic Process
Glutathione Derivative Biosynthetic Process
Regulation Of Cell Growth
Cellular Iron Ion Homeostasis
Positive Regulation Of Plasminogen Activation
Regulation Of Cell Proliferation
Positive Regulation Of Extracellular Matrix Disassembly
Iron Ion Import
Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Metabolism of lipids and lipoproteins
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective UGT1A4 causes hyperbilirubinemia
Glutathione conjugation
Metabolic disorders of biological oxidation enzymes
Arachidonic acid metabolism
Phase II conjugation
Defective UGT1A1 causes hyperbilirubinemia
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Glutathione
2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride
Glycerol
3-phenyl-5-(1H-pyrazol-3-yl)isoxazole
PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE
2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid
4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE
nocodazole
3-(4-nitrophenyl)-1H-pyrazole
1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS
Testicular germ cell tumor (
23666239
)
Protein-Protein Interactions
4 interactors:
ABHD17A
ARRDC3
HK3
MFI2
5 interactors:
DERL1
DERL2
DERL3
HPGDS
NOTCH2NL
Entrez ID
27306
4241
HPRD ID
04001
01122
Ensembl ID
ENSG00000163106
ENSG00000163975
Uniprot IDs
O60760
P08582
Q53XS6
PDB IDs
1IYH
1IYI
1V40
2CVD
2VCQ
2VCW
2VCX
2VCZ
2VD0
2VD1
3EE2
3KXO
3VI5
3VI7
4EC0
4EDY
4EDZ
4EE0
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Locomotion Involved In Locomotory Behavior
Negative Regulation Of Heat Generation
Positive Regulation Of Adrenergic Receptor Signaling Pathway
Regulation Of Locomotion Involved In Locomotory Behavior
Positive Regulation Of Extracellular Matrix Disassembly
Homeostatic Process
Positive Regulation Of Plasminogen Activation
Regulation Of Adrenergic Receptor Signaling Pathway
Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Fat Pad Development
Negative Regulation Of Multicellular Organismal Metabolic Process
Iron Ion Import
Cellular Chemical Homeostasis
Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Positive Regulation Of Protein Processing
Temperature Homeostasis
Cellular Homeostasis
Regulation Of Extracellular Matrix Disassembly
Regulation Of Substrate Adhesion-dependent Cell Spreading
Glucose 6-phosphate Metabolic Process
Adipose Tissue Development
Regulation Of Extracellular Matrix Organization
Chemical Homeostasis
Negative Regulation Of Cell-substrate Adhesion
Carbohydrate Phosphorylation
Glucose Transport
Positive Regulation Of Ubiquitin-protein Transferase Activity
Cellular Glucose Homeostasis
Positive Regulation Of Ligase Activity
Hexose Transport
Iron Ion Transport
ER-associated Ubiquitin-dependent Protein Catabolic Process
Retrograde Protein Transport, ER To Cytosol
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Topologically Incorrect Protein
Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Signal Transduction
Signaling
Cell Communication
Intracellular Transport Of Viral Protein In Host Cell
Cellular Response To Stimulus
Cellular Response To Stress
Proteolysis
Cyclooxygenase Pathway
Catabolic Process
Cellular Response To Organic Substance
Prostaglandin Biosynthetic Process
Suckling Behavior
Glutathione Derivative Biosynthetic Process
Response To Stimulus
Protein Destabilization
Intracellular Transport Of Virus
Behavior
Prostaglandin Metabolic Process
Icosanoid Biosynthetic Process
Response To Organic Substance
Unsaturated Fatty Acid Biosynthetic Process
Intracellular Protein Transport
Arachidonic Acid Metabolic Process
Icosanoid Metabolic Process
Feeding Behavior
Protein N-linked Glycosylation Via Asparagine
Interaction With Host
Unsaturated Fatty Acid Metabolic Process
Response To Stress
Tagcloud
?
11beta
9alpha
abcc4
akr1b1
akr1c1
akr1c3
catalyze
diseased
endometriosis
endometriotic
endometrium
gynecological
hieec
hiesc
infertility
peritoneal
pgd2
pgf2alpha
pgh2
pla2g2a
pla2g4a
provokes
ptgds
ptgfr
ptgs2
reaches
slco2a
synthases
Tagcloud (Difference)
?
11beta
9alpha
abcc4
akr1b1
akr1c1
akr1c3
catalyze
diseased
endometriosis
endometriotic
endometrium
gynecological
hieec
hiesc
infertility
peritoneal
pgd2
pgf2alpha
pgh2
pla2g2a
pla2g4a
provokes
ptgds
ptgfr
ptgs2
reaches
slco2a
synthases
Tagcloud (Intersection)
?