HPGDS

Gene Name		hematopoietic prostaglandin D synthase
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Homodimerization Activity
	Biological Process	Prostaglandin Metabolic Process Xenobiotic Metabolic Process Signal Transduction Locomotory Behavior Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glycerol 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-protein Interactions		4 interactors: ABHD17A ARRDC3 HK3 MFI2
Entrez ID		27306
HPRD ID		04001
Ensembl ID		ENSG00000163106
Uniprot IDs		O60760
PDB IDs		1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Heat Generation Positive Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Extracellular Matrix Disassembly Homeostatic Process Positive Regulation Of Plasminogen Activation Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Fat Pad Development Negative Regulation Of Multicellular Organismal Metabolic Process Iron Ion Import Cellular Chemical Homeostasis Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Temperature Homeostasis Cellular Homeostasis Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Glucose 6-phosphate Metabolic Process Adipose Tissue Development Regulation Of Extracellular Matrix Organization Chemical Homeostasis Negative Regulation Of Cell-substrate Adhesion Carbohydrate Phosphorylation Glucose Transport Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Glucose Homeostasis Positive Regulation Of Ligase Activity Hexose Transport Iron Ion Transport
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases