LDHC and RBL2

Number of citations of the paper that reports this interaction (PubMedID 16600870)
0

Data Source:
BioGRID (two hybrid)

		LDHC	RBL2
Description		lactate dehydrogenase C	RB transcriptional corepressor like 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Cilium Motile Cilium Extracellular Exosome Oxidoreductase Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Lactate Metabolic Process ATP Biosynthetic Process Lactate Biosynthetic Process From Pyruvate Carboxylic Acid Metabolic Process Flagellated Sperm Motility Pyruvate Catabolic Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Pyruvate metabolism	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs		NADH
Diseases
GWAS		Amyloid A serum levels ( 21124955) Amyotrophic lateral sclerosis (sporadic) ( 24529757)	Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: BRCA1 RBL2 SRPK2	46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		3948	5934
HPRD ID		01027	01576
Ensembl ID		ENSG00000166796	ENSG00000103479
Uniprot IDs		A0A140VKA7 P07864	Q08999
PDB IDs		7EPM	4XI9 5C1D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Centriole Replication BRCA1-B Complex Histone H2AK127 Ubiquitin Ligase Activity Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Negative Regulation Of Cell Cycle Process BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Cell Cycle Phase Transition Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Chromosome BRCA1-BARD1 Complex Regulation Of Cell Cycle Chromatin Organization Regulation Of Lipid Kinase Activity Nuclear Speck Organization TIM22 Mitochondrial Import Inner Membrane Insertion Complex Mitochondrial Intermembrane Space Chaperone Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity R-loop Processing Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Centrosome Duplication XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Protein Transporter Activity Regulation Of Cell Cycle Phase Transition Nuclear Body Organization Protein Insertion Into Mitochondrial Inner Membrane RNA Polymerase Binding Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly
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