LDHC and TIMM10B

Data Source: HiPPIP (Novel)

		LDHC	TIMM10B
Name		lactate dehydrogenase C	translocase of inner mitochondrial membrane 10B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Cilium Motile Cilium Extracellular Exosome Oxidoreductase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding Metal Ion Binding Unfolded Protein Binding Protein Transporter Activity
	Biological Process	Lactate Metabolic Process ATP Biosynthetic Process Lactate Biosynthetic Process From Pyruvate Carboxylic Acid Metabolic Process Flagellated Sperm Motility Pyruvate Catabolic Process	Cell-matrix Adhesion Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways		Pyruvate metabolism	Mitochondrial protein import
Drugs		NADH	None
GWAS		Amyloid A serum levels ( 21124955 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 )	Malaria ( 31844061 )
Novel Interactors		1 novel interactors: TIMM10B	3 novel interactors: LDHC PLD2 RPLP2
Interacting Genes		3 interacting genes: BRCA1 RBL2 SRPK2	5 interacting genes: EIF3F HGS KLHL38 MBD3 MEIS2
Entrez ID		3948	26515
HPRD ID		01027	16242
Ensembl ID		ENSG00000166796	ENSG00000132286
Uniprot IDs		A0A140VKA7 P07864	B2R4A9 Q9Y5J6
PDB IDs		7EPM	7CGP
GO Terms Enriched among Interactors		Negative Regulation Of Centriole Replication BRCA1-B Complex Histone H2AK127 Ubiquitin Ligase Activity Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Negative Regulation Of Cell Cycle Process BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Cell Cycle Phase Transition Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Chromosome BRCA1-BARD1 Complex Regulation Of Cell Cycle Chromatin Organization Regulation Of Lipid Kinase Activity Nuclear Speck Organization TIM22 Mitochondrial Import Inner Membrane Insertion Complex Mitochondrial Intermembrane Space Chaperone Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity R-loop Processing Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Centrosome Duplication XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Protein Transporter Activity Regulation Of Cell Cycle Phase Transition Nuclear Body Organization Protein Insertion Into Mitochondrial Inner Membrane RNA Polymerase Binding Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint	None