LAIR2 and EMILIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAIR2	EMILIN1
Description		leukocyte associated immunoglobulin like receptor 2	elastin microfibril interfacer 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix Integrin Alpha4-beta1 Complex Extracellular Exosome EMILIN Complex
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Molecular Adaptor Activity Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Immune Response-regulating Signaling Pathway	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Platelet Aggregation Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: EMILIN1 LCN2 SGTA UBQLN1 UBQLN2	28 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TSNAX YJU2 ZC2HC1C ZNF655
Entrez ID		3904	11117
HPRD ID		04293	00563
Ensembl ID		ENSG00000167618	ENSG00000138080
Uniprot IDs		Q6ISS4	Q9Y6C2
PDB IDs			2KA3 2OII
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Identical Protein Binding Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Hippocampal Neuron Apoptotic Process Autophagosome Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Regulation Of Cellular Response To Stress TRC Complex Positive Regulation Of Catabolic Process EMILIN Complex Autophagosome Organization Autophagosome Assembly Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Siderophore Transport Cellular Response To Hypoxia Cellular Response To Stress Protein Catabolic Process Integrin Alpha4-beta1 Complex Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen Levels Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process	A2A Adenosine Receptor Binding
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