SLC9A4 and CHP1

Number of citations of the paper that reports this interaction (PMID 12576672)
8

Data Source:
HPRD (in vivo, in vitro)

		SLC9A4	CHP1
Gene Name		solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	calcineurin-like EF-hand protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion Microtubule Cytoskeleton Transport Vesicle Extracellular Vesicular Exosome
	Molecular Function	Sodium:proton Antiporter Activity	Protein Kinase Inhibitor Activity Transporter Activity Calcium Ion Binding Protein Binding Microtubule Binding Potassium Channel Regulator Activity Kinase Binding Calcium-dependent Protein Binding
	Biological Process	Gastric Acid Secretion Epithelial Cell Development Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Carbohydrate Metabolic Process Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase Mediated Signal Transduction Pathogenesis Negative Regulation Of Phosphatase Activity Calcium Ion-dependent Exocytosis Membrane Docking Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Transcytosis Protein Stabilization Positive Regulation Of Protein Transport Protein Oligomerization Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Death
Pathways		Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Celiac disease ( 18311140) White blood cell types ( 21738478)
Protein-Protein Interactions		2 interactors: CHP1 CHP2	9 interactors: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B
Entrez ID		389015	11261
HPRD ID		15973	06101
Ensembl ID		ENSG00000180251	ENSG00000187446
Uniprot IDs		Q6AI14	H0YKE7 Q99653
PDB IDs			2E30
Enriched GO Terms of Interacting Partners?		Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Regulation Of Phosphatase Activity Regulation Of Dephosphorylation Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Transport Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Intracellular Transport Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Acidic PH Negative Regulation Of Calcium-mediated Signaling Regulation Of Protein Transport Regulation Of Protein Glycosylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Transport Transcytosis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Hyaluronan Catabolic Process Regulation Of Protein Localization Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To PH Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Response To Acidic PH Regulation Of Cellular Localization Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycoprotein Biosynthetic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Cellular Response To Heat Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphatase Activity Positive Regulation Of Protein Targeting To Membrane Regulation Of Sodium Ion Transmembrane Transport Response To PH Positive Regulation Of Sodium Ion Transport Protein Export From Nucleus Cytoplasmic Microtubule Organization Hyaluronan Metabolic Process Regulation Of Centrosome Duplication	Regulation Of PH Hydrogen Ion Transmembrane Transport Sodium Ion Transmembrane Transport Proton Transport Sodium Ion Transport Ion Homeostasis Monovalent Inorganic Cation Transport Metal Ion Transport Chemical Homeostasis Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Neuron Death Sodium Ion Import Across Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Cell Death Death Sodium Ion Import Cardiac Muscle Cell Contraction Regulation Of The Force Of Heart Contraction By Cardiac Conduction Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of The Force Of Heart Contraction Peptidyl-cysteine S-nitrosylation Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Pathogenesis Sodium Ion Export Positive Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Acidic PH Positive Regulation Of Action Potential Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Transport Gastric Acid Secretion Cellular Response To Electrical Stimulus Maintenance Of Cell Polarity Regulation Of Calcineurin-NFAT Signaling Cascade Apoptotic Process Cellular Sodium Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Hyaluronan Catabolic Process Programmed Cell Death Mitochondrion Transport Along Microtubule Cellular Response To PH Positive Regulation Of Sodium Ion Transmembrane Transport Establishment Of Mitochondrion Localization Cellular Response To Epinephrine Stimulus
Tagcloud ?			antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting
Tagcloud (Difference) ?			antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting
Tagcloud (Intersection) ?