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SLC9A4 and CHP1
Number of citations of the paper that reports this interaction (PMID
12576672
)
8
Data Source:
HPRD
(in vivo, in vitro)
SLC9A4
CHP1
Gene Name
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
calcineurin-like EF-hand protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Golgi Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
Microtubule Cytoskeleton
Transport Vesicle
Extracellular Vesicular Exosome
Molecular Function
Sodium:proton Antiporter Activity
Protein Kinase Inhibitor Activity
Transporter Activity
Calcium Ion Binding
Protein Binding
Microtubule Binding
Potassium Channel Regulator Activity
Kinase Binding
Calcium-dependent Protein Binding
Biological Process
Gastric Acid Secretion
Epithelial Cell Development
Ion Transport
Regulation Of PH
Sodium Ion Transmembrane Transport
Transmembrane Transport
Hydrogen Ion Transmembrane Transport
Microtubule Bundle Formation
Negative Regulation Of Protein Phosphorylation
Carbohydrate Metabolic Process
Negative Regulation Of Protein Kinase Activity
Protein Export From Nucleus
Potassium Ion Transport
Small GTPase Mediated Signal Transduction
Pathogenesis
Negative Regulation Of Phosphatase Activity
Calcium Ion-dependent Exocytosis
Membrane Docking
Glycosaminoglycan Metabolic Process
Hyaluronan Metabolic Process
Hyaluronan Catabolic Process
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Autophosphorylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Protein Import Into Nucleus
Small Molecule Metabolic Process
Transcytosis
Protein Stabilization
Positive Regulation Of Protein Transport
Protein Oligomerization
Regulation Of Intracellular PH
Positive Regulation Of Protein Glycosylation
Membrane Organization
Membrane Fusion
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Acidic PH
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Neuron Death
Pathways
Sodium/Proton exchangers
Transport of inorganic cations/anions and amino acids/oligopeptides
SLC-mediated transmembrane transport
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Defective B4GALT7 causes EDS, progeroid type
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
Hyaluronan uptake and degradation
Defective CHST14 causes EDS, musculocontractural type
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
Hyaluronan metabolism
Defective CHST6 causes MCDC1
MPS IIIC - Sanfilippo syndrome C
Diseases associated with glycosaminoglycan metabolism
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
MPS IV - Morquio syndrome A
MPS IV - Morquio syndrome B
Defective CHSY1 causes TPBS
Metabolism of carbohydrates
MPS VII - Sly syndrome
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Celiac disease (
18311140
)
White blood cell types (
21738478
)
Protein-Protein Interactions
2 interactors:
CHP1
CHP2
9 interactors:
GAPDH
KIF1B
PRSS23
SLC9A1
SLC9A2
SLC9A3
SLC9A4
SLC9A5
STK17B
Entrez ID
389015
11261
HPRD ID
15973
06101
Ensembl ID
ENSG00000180251
ENSG00000187446
Uniprot IDs
Q6AI14
H0YKE7
Q99653
PDB IDs
2E30
Enriched GO Terms of Interacting Partners
?
Regulation Of Calcineurin-NFAT Signaling Cascade
Regulation Of Calcium-mediated Signaling
Regulation Of Phosphatase Activity
Regulation Of Dephosphorylation
Positive Regulation Of Intracellular Protein Transport
Regulation Of Protein Import Into Nucleus
Regulation Of Protein Localization To Nucleus
Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Intracellular Transport
Regulation Of Intracellular Protein Transport
Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Transport
Positive Regulation Of Sodium:proton Antiporter Activity
Positive Regulation Of Protein Glycosylation
Regulation Of Intracellular Transport
Regulation Of Sodium:proton Antiporter Activity
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Acidic PH
Negative Regulation Of Calcium-mediated Signaling
Regulation Of Protein Transport
Regulation Of Protein Glycosylation
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Protein Autophosphorylation
Positive Regulation Of Transport
Transcytosis
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Proton Transport
Hyaluronan Catabolic Process
Regulation Of Protein Localization
Positive Regulation Of Glycoprotein Biosynthetic Process
Cellular Response To PH
Positive Regulation Of Glycoprotein Metabolic Process
Positive Regulation Of Sodium Ion Transmembrane Transport
Response To Acidic PH
Regulation Of Cellular Localization
Positive Regulation Of Calcium-mediated Signaling
Regulation Of Glycoprotein Biosynthetic Process
Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Cellular Response To Heat
Regulation Of Protein Autophosphorylation
Positive Regulation Of Phosphatase Activity
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Sodium Ion Transmembrane Transport
Response To PH
Positive Regulation Of Sodium Ion Transport
Protein Export From Nucleus
Cytoplasmic Microtubule Organization
Hyaluronan Metabolic Process
Regulation Of Centrosome Duplication
Regulation Of PH
Hydrogen Ion Transmembrane Transport
Sodium Ion Transmembrane Transport
Proton Transport
Sodium Ion Transport
Ion Homeostasis
Monovalent Inorganic Cation Transport
Metal Ion Transport
Chemical Homeostasis
Cation Transmembrane Transport
Cation Transport
Ion Transmembrane Transport
Homeostatic Process
Transmembrane Transport
Ion Transport
Neuron Death
Sodium Ion Import Across Plasma Membrane
Peptidyl-cysteine S-trans-nitrosylation
Cell Death
Death
Sodium Ion Import
Cardiac Muscle Cell Contraction
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Positive Regulation Of Calcium:sodium Antiporter Activity
Positive Regulation Of The Force Of Heart Contraction
Peptidyl-cysteine S-nitrosylation
Positive Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Pathogenesis
Sodium Ion Export
Positive Regulation Of NFAT Protein Import Into Nucleus
Cellular Response To Acidic PH
Positive Regulation Of Action Potential
Response To Muscle Stretch
Regulation Of Cardiac Muscle Cell Membrane Potential
Transport
Gastric Acid Secretion
Cellular Response To Electrical Stimulus
Maintenance Of Cell Polarity
Regulation Of Calcineurin-NFAT Signaling Cascade
Apoptotic Process
Cellular Sodium Ion Homeostasis
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Hyaluronan Catabolic Process
Programmed Cell Death
Mitochondrion Transport Along Microtubule
Cellular Response To PH
Positive Regulation Of Sodium Ion Transmembrane Transport
Establishment Of Mitochondrion Localization
Cellular Response To Epinephrine Stimulus
Tagcloud
?
antisilencing
associating
chromodomain
clr4
comprise
coordinates
determinant
disrupted
dissecting
dsr
eliminating
epe1
facultative
fission
follows
h3k9
heterochromatin
machinery
mechanistically
mei4
meiotic
mmi1
participates
recruits
red1
reversibly
ssm4
suv39h
transacting
Tagcloud (Difference)
?
antisilencing
associating
chromodomain
clr4
comprise
coordinates
determinant
disrupted
dissecting
dsr
eliminating
epe1
facultative
fission
follows
h3k9
heterochromatin
machinery
mechanistically
mei4
meiotic
mmi1
participates
recruits
red1
reversibly
ssm4
suv39h
transacting
Tagcloud (Intersection)
?