C2orf68 and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C2orf68	SIVA1
Description		chromosome 2 open reading frame 68	SIVA1 apoptosis inducing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process		Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		12 interacting genes: AXIN2 HYPK KANK2 KEAP1 KRT40 KRTAP1-3 KRTAP10-8 RAB3IL1 SIVA1 SPRED1 TNNI1 ZBTB14	33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446
Entrez ID		388969	10572
HPRD ID		18391	16124
Ensembl ID		ENSG00000168887	ENSG00000184990
Uniprot IDs		L7T9J5 Q2NKX9	O15304
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport
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