HRNR and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		HRNR	RNF26
Description		hornerin	ring finger protein 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Extracellular Matrix Azurophil Granule Lumen Keratohyalin Granule Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Calcium Ion Binding Metal Ion Binding Transition Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Keratinization Cell Envelope Organization Establishment Of Skin Barrier	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		Neutrophil degranulation
Drugs		Zinc Zinc acetate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Itch intensity from mosquito bite ( 28199695) Male-pattern baldness ( 28196072)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: HSP90AA1 LINC00624 RNF26 UBC USP7	54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1
Entrez ID		388697	79102
HPRD ID		17114	05842
Ensembl ID		ENSG00000197915	ENSG00000173456
Uniprot IDs		Q86YZ3	Q9BY78
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus CTP Binding DATP Binding Regulation Of Type I Interferon Production Neurofibrillary Tangle Assembly UTP Binding Regulation Of Telomere Maintenance Sulfonylurea Receptor Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Rho GDP-dissociation Inhibitor Binding Symbiont-mediated Disruption Of Host Cell PML Body Post-translational Protein Modification Chaperone-mediated Autophagy Macromolecule Catabolic Process Sperm Mitochondrial Sheath Nitric-oxide Synthase Regulator Activity Protein Stabilization Regulation Of Intracellular Transport Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Regulation Of Chromosome Organization Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Protein Localization To Perinuclear Region Of Cytoplasm Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Monoubiquitinated Protein Deubiquitination Ubiquitin Protein Ligase Binding Proteolysis DNA Alkylation Repair Positive Regulation Of Cell Size Protein Unfolding Transcription-coupled Nucleotide-excision Repair Protein Metabolic Process Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Striated Muscle Contraction Striated Muscle Cell Apoptotic Process Regulation Of Telomere Capping Regulation Of Protein Catabolic Process Regulation Of Protein Stability Protein Tag Activity Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Enzyme-substrate Adaptor Activity Negative Regulation Of Defense Response To Virus Endocytic Vesicle Lumen Response To Salt Stress	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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