CCL4L1 and CCL2

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL4L1	CCL2
Description		C-C motif chemokine ligand 4 like 1	C-C motif chemokine ligand 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Protein Kinase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Positive Regulation Of Cell Migration Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Positive Regulation Of Cell Migration Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Synaptic Transmission, Glutamatergic Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Calcium Ion Import Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling G alpha (i) signalling events	Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling NFE2L2 regulating inflammation associated genes
Drugs			Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Body mass index ( 26426971) Macrophage inflammatory protein 1b levels ( 27989323)	Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		3 interacting genes: CCL2 CXCL13 PF4V1	28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2
Entrez ID		388372	6347
HPRD ID		16689	01149
Ensembl ID			ENSG00000108691
Uniprot IDs		P13236 Q8NHW4	P13500
PDB IDs		1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL	1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9 7SO0 7XA3 8FJ0
Enriched GO Terms of Interacting Partners?		Chemokine Activity Granulocyte Chemotaxis Granulocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Antimicrobial Humoral Response Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Chemotaxis Cellular Response To Molecule Of Bacterial Origin Cytokine Activity Leukocyte Migration Humoral Immune Response Response To Lipopolysaccharide Regulation Of Lymphocyte Chemotaxis Response To Molecule Of Bacterial Origin Chemotaxis Locomotion Cellular Response To Lipid Negative Regulation Of Chemotaxis Neutrophil Chemotaxis Lymphocyte Migration Inflammatory Response Neutrophil Migration Regulation Of Lymphocyte Migration Chemokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Response To Lipid Mononuclear Cell Migration Cellular Response To Oxygen-containing Compound Cell Migration Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Heparin Binding Response To Other Organism Immune Response Negative Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To External Biotic Stimulus	Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Chemokine Activity Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration G Protein-coupled Receptor Signaling Pathway Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Motility CCR Chemokine Receptor Binding Myeloid Leukocyte Migration Antimicrobial Humoral Response Leukocyte Migration Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Cytokine Activity Humoral Immune Response Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Immune System Process Defense Response Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Positive Regulation Of Cell Motility Defense Response To Other Organism Positive Regulation Of Locomotion Extracellular Space Response To External Biotic Stimulus Calcium-mediated Signaling Regulation Of Cell Migration Extracellular Region Mononuclear Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Killing Of Cells Of Another Organism Monocyte Chemotaxis Response To Other Organism Response To Stress Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Lipopolysaccharide Intracellular Calcium Ion Homeostasis Regulation Of Neuroinflammatory Response
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