KRT17 and KRT8

Number of citations of the paper that reports this interaction (PMID 9630597)
2

Data Source:
BioGRID (two hybrid)

		KRT17	KRT8
Gene Name		keratin 17, type I	keratin 8, type II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Intermediate Filament Extracellular Vesicular Exosome Cell Periphery	Nucleus Nucleoplasm Cytoplasm Intermediate Filament Cell-cell Junction Dystrophin-associated Glycoprotein Complex Nuclear Matrix Z Disc Sarcolemma Costamere Keratin Filament Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding MHC Class II Receptor Activity MHC Class II Protein Binding	Structural Molecule Activity Protein Binding Protein Complex Binding Scaffold Protein Binding
	Biological Process	Signal Transduction Epidermis Development Positive Regulation Of Cell Growth Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development	Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Sarcomere Organization Response To Hydrostatic Pressure Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		10 interactors: APC CCDC85B EGFR KDM1A KRT6A KRT7 KRT72 KRT8 TRIM69 ZDHHC17	35 interactors: ANXA1 BYSL DEDD DMD EGFR FBXO25 FGFR3 GRB2 HSPA5 IKBKG KPNA2 KRT13 KRT15 KRT17 KRT18 KRT31 KRT38 KRT40 MAPK1 MAPK14 MAPK3 MAPK8 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO1 SUMO2 SUMO3 TCHP TFIP11 TROAP
Entrez ID		3872	3856
HPRD ID		01019	01015
Ensembl ID		ENSG00000128422	ENSG00000170421
Uniprot IDs		Q04695 Q14666	P05787 Q7L4M3
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Chromosome Organization Hair Follicle Development Hair Cycle Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Astrocyte Activation Hair Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Gland Development Embryonic Placenta Development In Utero Embryonic Development Cell Differentiation Negative Regulation Of Protein Catabolic Process Regulation Of Response To DNA Damage Stimulus Activation Of Phospholipase A2 Activity Negative Regulation Of Odontogenesis Positive Regulation Of Phospholipase A2 Activity Muscle Cell Development Regulation Of Cell Proliferation Regulation Of Myeloid Cell Differentiation Response To Cobalamin Response To UV-A Placenta Development Response To Hydroxyisoflavone Metaphase/anaphase Transition Of Mitotic Cell Cycle Histone H3-K9 Demethylation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Histone H3-K4 Methylation Response To Hydrostatic Pressure Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Histone H3-K4 Demethylation Regulation Of Chromosome Organization	Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Tissue Development Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Positive Regulation Of Protein Metabolic Process Programmed Cell Death Innate Immune Response Cell Death Death Immune Response-regulating Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Organic Substance Positive Regulation Of Transferase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Lipid Response To Growth Factor Anatomical Structure Development Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Defense Response Developmental Process Epithelium Development Response To Abiotic Stimulus Regulation Of Immune Response Positive Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process
Tagcloud ?		aggressiveness axis basal blbc comprised concurrent cytokeratin cytokeratins cytoskeleton erk1 gaba gabrp hcc1187 hcc70 inherent krt14 krt5 krt6b maintains migratory poorer postulate protrusions silenced stably subtype therapeutics tn tumorigenic	ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Difference) ?		aggressiveness axis basal blbc comprised concurrent cytokeratin cytokeratins cytoskeleton erk1 gaba gabrp hcc1187 hcc70 inherent krt14 krt5 krt6b maintains migratory poorer postulate protrusions silenced stably subtype therapeutics tn tumorigenic	ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Intersection) ?