KRT72 and KRT16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT72	KRT16
Description		keratin 72	keratin 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Cornified Envelope Nucleus Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Keratinization Intermediate Filament Organization	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Keratinocyte Migration Establishment Of Skin Barrier
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex Non-epidermolytic palmoplantar keratoderma (NEPPK)
GWAS		High density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		25 interacting genes: BLOC1S6 HSPB1 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT20 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 UBC	53 interacting genes: AIRIM AMOT ARFIP2 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 DRC4 EPM2AIP1 GNG10 HGS KIFC3 KLC4 KRT1 KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1
Entrez ID		140807	3868
HPRD ID		09746	01018
Ensembl ID		ENSG00000170486	ENSG00000186832
Uniprot IDs		B4DXK4 Q14CN4	P08779
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Morphogenesis Of An Epithelium Epithelial Cell Differentiation Cytoskeleton Organization Tissue Morphogenesis Cytoskeleton Organelle Organization Anatomical Structure Morphogenesis Extracellular Exosome Cytosol Cell Differentiation Cellular Developmental Process Hair Cycle Intermediate Filament Cytoskeleton Structural Constituent Of Cytoskeleton Developmental Process Keratinization Epidermis Development Hair Follicle Morphogenesis Cornified Envelope Tissue Development Hair Cycle Process Cell Periphery Keratin Filament Binding Negative Regulation Of Protein Kinase C Signaling Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle	Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Cytosol
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