KRT25 and KRT6B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT25	KRT6B
Description		keratin 25	keratin 6B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Cytosol Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Cytoskeleton Organization Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cycle Intermediate Filament Organization	Ectoderm Development Keratinization Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Asthma ( 30929738 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		26 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 MORN4 PPL	30 interacting genes: GOLGA2 KDM1A KIFC3 KRT13 KRT15 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LINC00839 NDC80 NUP62 OIP5 PDE4B SMARCB1 TEX11 TFIP11 TRIM54 TUBGCP4
Entrez ID		147183	3854
HPRD ID		17242	01012
Ensembl ID		ENSG00000204897	ENSG00000185479
Uniprot IDs		Q6ZPD6 Q7Z3Z0	P04259
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Cytosol Cornified Envelope Epidermis Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Tissue Development Peptide Cross-linking Desmosome Intermediate Filament Polymerization Protein Binding Structural Molecule Activity Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Negative Regulation Of Entry Of Bacterium Into Host Cell Response To Wounding	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Morphogenesis Of An Epithelium Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Organelle Organization Anatomical Structure Morphogenesis Cell Differentiation Cellular Developmental Process Extracellular Exosome Structural Constituent Of Cytoskeleton Developmental Process Cytosol Hair Follicle Morphogenesis Epidermis Development Gamma-tubulin Complex Hair Cycle Meiotic Spindle Assembly Hair Cycle Process Spindle Assembly Meiotic Spindle Organization Microtubule Binding Microtubule Nucleation Membraneless Organelle Assembly Intermediate Filament Polymerization Gamma-tubulin Binding Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Kinetochore Adaptor Activity Meiotic Gene Conversion Z Disc Chromosome Segregation
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