NUP98 and NUP205

Number of citations of the paper that reports this interaction (PubMedID 35679425)
148

Data Source:
BioGRID (pull down, cross-linking study)

		NUP98	NUP205
Description		nucleoporin 98 and 96 precursor	nucleoporin 205
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Pore Inner Ring
	Molecular Function	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Nuclear Localization Sequence Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Structural Constituent Of Nuclear Pore Peptide Binding Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Telomere Tethering At Nuclear Periphery Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly	Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport MRNA Transport Nuclear Pore Complex Assembly
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)	Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Meat-related diet ( 32066663) Paget's disease ( 21623375) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NUP133 NUP188 NUP205 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR	4 interacting genes: HOXC10 NUP35 NUP93 NUP98
Entrez ID		4928	23165
HPRD ID		03012	17653
Ensembl ID		ENSG00000110713	ENSG00000155561
Uniprot IDs		A0A8V8TR21 H0YCR0 H0YEN4 P52948	Q92621
PDB IDs		1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM 7F60 7F90 7MNI 7PEQ 7Q64 7Q65 7Q66 7Q67 7VPG 7VPH 8CI8	5IJN 5IJO 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Envelope RNA Transport Structural Constituent Of Nuclear Pore Protein Localization To Nucleus MRNA Transport Nucleobase-containing Compound Transport Establishment Of Protein Localization To Organelle RNA Export From Nucleus Protein Localization To Organelle Intracellular Transport Nuclear Export Intracellular Protein Transport Protein Transport Nuclear Localization Sequence Binding Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell MRNA Export From Nucleus Intracellular Protein Localization Regulation Of Mitotic Spindle Organization Nuclear Import Signal Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Nucleoplasm Cytosol Nuclear Pore Organization Histone H3K27 Acetyltransferase Activity Regulation Of Cytoskeleton Organization Nucleus Regulation Of Microtubule-based Process Nuclear Membrane Regulation Of Mitotic Spindle Assembly Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Pore Inner Ring Small GTPase Binding Regulation Of Cell Cycle Kinetochore Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Nucleus Organization Regulation Of Spindle Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus	Nuclear Pore Organization Structural Constituent Of Nuclear Pore Nucleus Organization Nuclear Pore Import Into Nucleus MRNA Transport Protein Import Into Nucleus Nuclear Pore Complex Assembly Nuclear Pore Nuclear Basket RNA Transport Nuclear Periphery Protein Localization To Nucleus Pore Complex Assembly Nucleobase-containing Compound Transport Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Nuclear Membrane Establishment Of Protein Localization To Organelle RNA Export From Nucleus Telomere Tethering At Nuclear Periphery Intracellular Protein Transport Activating MHC Class I Receptor Activity Negative Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Protein Localization To Organelle Nuclear Export Negative Regulation Of Adaptive Immune Memory Response Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Negative Regulation Of T Cell Costimulation Nuclear Pore Cytoplasmic Filaments MHC Class I Receptor Activity Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell MHC Class Ib Receptor Activity Nuclear Pore Central Transport Channel Spinal Cord Motor Neuron Cell Fate Specification Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MHC Class I Protein Complex Binding Protein Transport Telomere Localization Positive Regulation Of Natural Killer Cell Cytokine Production Nuclear Pore Outer Ring Intracellular Transport Regulation Of Natural Killer Cell Cytokine Production Nuclear Inclusion Body Establishment Of Protein Localization Nuclear Body Protein-containing Complex Organization Positive Regulation Of Immune Response To Tumor Cell Cellular Localization
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