GGT1

Gene Name		gamma-glutamyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Gamma-glutamyltransferase Activity Protein Binding Glutathione Hydrolase Activity
	Biological Process	Regulation Of Immune System Process Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Zymogen Activation Small Molecule Metabolic Process Regulation Of Inflammatory Response Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Metabolic disorders of biological oxidation enzymes Glutathione conjugation Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione
Diseases
GWAS		Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913)
Protein-protein Interactions		3 interactors: CD53 KCNMA1 NAMPT
Entrez ID		2678
HPRD ID		01980
Ensembl ID		ENSG00000100031
Uniprot IDs		P19440
PDB IDs		4GDX 4GG2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Nicotinamide Metabolic Process Micturition Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Potassium Ion Homeostasis Positive Regulation Of Myoblast Fusion Regulation Of Myoblast Fusion Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion NAD Biosynthetic Process Cell Volume Homeostasis Positive Regulation Of Myotube Differentiation Cell-cell Signaling Excretion NAD Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Myotube Differentiation Smooth Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Circadian Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Positive Regulation Of Muscle Cell Differentiation Response To Osmotic Stress Renal System Process Regulation Of Striated Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation Signaling Vitamin Metabolic Process Cell Communication
Tagcloud ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu