GGT1 and CD53

Number of citations of the paper that reports this interaction (PMID 9862348)
8

Data Source:
HPRD (in vivo)

		GGT1	CD53
Gene Name		gamma-glutamyltransferase 1	CD53 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome	Immunological Synapse Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Gamma-glutamyltransferase Activity Protein Binding Glutathione Hydrolase Activity	Protein Binding
	Biological Process	Regulation Of Immune System Process Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Zymogen Activation Small Molecule Metabolic Process Regulation Of Inflammatory Response Glutathione Derivative Biosynthetic Process	Signal Transduction Positive Regulation Of Myoblast Fusion
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Metabolic disorders of biological oxidation enzymes Glutathione conjugation Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione
Diseases
GWAS		Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913)	Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: CD53 KCNMA1 NAMPT	6 interactors: CD2 CD4 CD9 GGT1 IL2 IL4
Entrez ID		2678	963
HPRD ID		01980	01054
Ensembl ID		ENSG00000100031	ENSG00000143119
Uniprot IDs		P19440	B4DQB5 P19397
PDB IDs		4GDX 4GG2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Nicotinamide Metabolic Process Micturition Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Potassium Ion Homeostasis Positive Regulation Of Myoblast Fusion Regulation Of Myoblast Fusion Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion NAD Biosynthetic Process Cell Volume Homeostasis Positive Regulation Of Myotube Differentiation Cell-cell Signaling Excretion NAD Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Myotube Differentiation Smooth Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Circadian Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Positive Regulation Of Muscle Cell Differentiation Response To Osmotic Stress Renal System Process Regulation Of Striated Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation Signaling Vitamin Metabolic Process Cell Communication	Cell Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Lymphocyte Activation Lymphocyte Activation Regulation Of Isotype Switching To IgG Isotypes Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of T Cell Differentiation Regulation Of Immune System Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Regulation Of Lymphocyte Differentiation Regulation Of Cell Adhesion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Isotype Switching Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Isotype Switching Positive Regulation Of Immune System Process Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Activated T Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation T Cell Selection Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interferon-gamma Production Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Natural Killer Cell Activation
Tagcloud ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Intersection) ?