GGT1 and NAMPT

Number of citations of the paper that reports this interaction (PMID 18486613)
4

Data Source:
BioGRID (two hybrid)

		GGT1	NAMPT
Gene Name		gamma-glutamyltransferase 1	nicotinamide phosphoribosyltransferase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Gamma-glutamyltransferase Activity Protein Binding Glutathione Hydrolase Activity	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Protein Homodimerization Activity Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Regulation Of Immune System Process Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Zymogen Activation Small Molecule Metabolic Process Regulation Of Inflammatory Response Glutathione Derivative Biosynthetic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Signal Transduction Cell-cell Signaling Female Pregnancy Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Response To Organic Cyclic Compound NAD Metabolic Process Circadian Regulation Of Gene Expression Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Metabolic disorders of biological oxidation enzymes Glutathione conjugation Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Glutathione
Diseases
GWAS		Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		3 interactors: CD53 KCNMA1 NAMPT	4 interactors: ADORA2A AKT2 FANCA GGT1
Entrez ID		2678	10135
HPRD ID		01980	09938
Ensembl ID		ENSG00000100031	ENSG00000105835
Uniprot IDs		P19440	P43490
PDB IDs		4GDX 4GG2	2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Nicotinamide Metabolic Process Micturition Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Potassium Ion Homeostasis Positive Regulation Of Myoblast Fusion Regulation Of Myoblast Fusion Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion NAD Biosynthetic Process Cell Volume Homeostasis Positive Regulation Of Myotube Differentiation Cell-cell Signaling Excretion NAD Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Myotube Differentiation Smooth Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Circadian Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Positive Regulation Of Muscle Cell Differentiation Response To Osmotic Stress Renal System Process Regulation Of Striated Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation Signaling Vitamin Metabolic Process Cell Communication	Glutathione Catabolic Process Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cysteine Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cysteine Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Adenosine Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Peptide Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process CAMP Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Lipid Transport Myelin Maintenance Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Positive Regulation Of Lipid Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Activation Of Adenylate Cyclase Activity Peptide Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glucose Import Cellular Response To Stimulus Myelination In Peripheral Nervous System CAMP Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Glucose Transport
Tagcloud ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Difference) ?		4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Intersection) ?