KCNJ8 and ABCC9

Number of citations of the paper that reports this interaction (PMID 11136227)
28

Data Source:
HPRD (in vitro)

		KCNJ8	ABCC9
Gene Name		potassium channel, inwardly rectifying subfamily J, member 8	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Myofibril Sarcolemma	Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Sarcomere Sarcolemma
	Molecular Function	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding	Transporter Activity Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity Potassium Channel Regulator Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding
	Biological Process	Kidney Development Potassium Ion Transport Synaptic Transmission Heart Development Response To PH Potassium Ion Import Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Vasodilation Response To Exogenous DsRNA Defense Response To Virus	Potassium Ion Transport Signal Transduction Synaptic Transmission Metabolic Process Potassium Ion Import Defense Response To Virus Transmembrane Transport
Pathways		Inwardly rectifying K+ channels ATP sensitive Potassium channels Potassium Channels	Inwardly rectifying K+ channels ABC-family proteins mediated transport ATP sensitive Potassium channels Potassium Channels
Drugs			Adenosine triphosphate Glyburide
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: ABCC8 ABCC9 KCNJ11 KCNJ2	5 interactors: EEF1G KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3764	10060
HPRD ID		02962	03258
Ensembl ID		ENSG00000121361	ENSG00000069431
Uniprot IDs		Q15842	O60706
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Monovalent Inorganic Cation Transport Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Transmembrane Transport Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Energy Reserve Metabolic Process Relaxation Of Skeletal Muscle Positive Regulation Of Ion Transport Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Regulation Of Membrane Potential Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Nicotine Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Regulation Of Protein Secretion Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Chemical Homeostasis Signaling Cell Communication Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transport Regulation Of Protein Transport Magnesium Ion Transport Regulation Of Secretion Response To ATP Regulation Of Establishment Of Protein Localization Cardiac Muscle Cell Action Potential Involved In Contraction	Potassium Ion Import Generation Of Precursor Metabolites And Energy Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Potassium Ion Transmembrane Transport Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Response To Virus Regulation Of Hormone Secretion Regulation Of Membrane Potential Cellular Response To Nicotine Energy Derivation By Oxidation Of Organic Compounds Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Oxidation-reduction Process Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Response To Gravity Positive Regulation Of Neurotransmitter Secretion Ion Transport Response To External Stimulus Response To Stimulus Glutamate Secretion Response To ATP Regulation Of Ion Transport Regulation Of Protein Transport Positive Regulation Of Cation Channel Activity Regulation Of Secretion Vasodilation Response To Ischemia Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Monovalent Inorganic Cation Transport Response To PH Regulation Of Establishment Of Protein Localization Response To Testosterone Substantia Nigra Development Response To Nicotine Cellular Response To Alkaloid Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Response To Other Organism Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Positive Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Biotic Stimulus
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Intersection) ?