KCNJ8 and ABCC9

Number of citations of the paper that reports this interaction (PubMedID 11136227)
37

Data Source:
HPRD (in vitro)

		KCNJ8	ABCC9
Description		potassium inwardly rectifying channel subfamily J member 8	ATP binding cassette subfamily C member 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Membrane Myofibril Potassium Ion-transporting ATPase Complex Protein-containing Complex Monoatomic Ion Channel Complex Sarcolemma Presynaptic Active Zone Membrane Presynapse Glutamatergic Synapse	Cytoplasm Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Sarcomere Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Nucleotide Binding Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Transmembrane Transporter Binding Protein-containing Complex Binding Potassium Channel Activator Activity ABC-type Transporter Activity
	Biological Process	Action Potential Blood Vessel Development Response To Hypoxia Microglial Cell Activation Kidney Development Vasculature Development Regulation Of Heart Rate Adaptive Immune Response Response To Ischemia Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Inflammatory Response Heart Development Regulation Of Blood Pressure Cell Population Proliferation Determination Of Adult Lifespan Protein Secretion Response To Xenobiotic Stimulus Gene Expression Fatty Acid Transport Transmission Of Nerve Impulse Establishment Of Cell Polarity Response To Lipopolysaccharide Response To Insulin Response To ATP Response To Cytokine Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress P38MAPK Cascade Vasodilation Response To Exogenous DsRNA NLRP3 Inflammasome Complex Assembly Fat Cell Differentiation Fibroblast Proliferation Nervous System Process Neuromuscular Process Synaptic Assembly At Neuromuscular Junction Defense Response To Virus Cardiac Pacemaker Cell Differentiation Atrioventricular Node Cell Differentiation Coronary Vasculature Development Glutamate Secretion, Neurotransmission CAMKK-AMPK Signaling Cascade Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Circulatory System Development Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Membrane Potential Reactive Gliosis Transport Across Blood-brain Barrier Response To Resveratrol Potassium Ion Import Across Plasma Membrane	MAPK Cascade Action Potential Blood Vessel Development Response To Hypoxia Heart Morphogenesis Vascular Process In Circulatory System Regulation Of Transcription By RNA Polymerase II Potassium Ion Transport Response To Stress Mitochondrion Organization Heart Development Skeletal Muscle Tissue Development Blood Circulation Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Response To Activity Fatty Acid Oxidation Response To ATP Response To Potassium Ion Cellular Response To Potassium Ion Response To Decreased Oxygen Levels Vasodilation Regulation Of Membrane Potential Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Response To Estrogen Cellular Respiration Negative Regulation Of Blood Pressure ATP Metabolic Process Fibroblast Proliferation Defense Response To Virus Transmembrane Transport Coronary Vasculature Development Cardiac Conduction Cellular Response To Chemical Stress Response To Oxygen Levels Cellular Response To Calcium Ion Cellular Response To ATP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Circulatory System Development Oxygen Metabolic Process Cardiac Muscle Cell Contraction Blood Vessel Diameter Maintenance Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Across Blood-brain Barrier Regulation Of Potassium Ion Transmembrane Transport Response To Peptide Reactive Oxygen Species Biosynthetic Process Response To Hydrogen Sulfide Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels	ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Drugs		Ritodrine Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben	ATP Glyburide Nicorandil
Diseases			Atrial fibrillation
GWAS		Birth weight ( 31043758)	Appendicular lean mass ( 33097823) Birth weight ( 27680694) Gout ( 22179738) Hippocampal sclerosis of aging ( 24770881) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54	6 interacting genes: EEF1G HSPB2 KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3764	10060
HPRD ID		02962	03258
Ensembl ID		ENSG00000121361	ENSG00000069431
Uniprot IDs		Q15842	O60706
PDB IDs
Enriched GO Terms of Interacting Partners?		Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion-transporting ATPase Complex Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Transmembrane Transporter Binding Inward Rectifier Potassium Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To ATP System Process Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Insulin Secretion ABC-type Transporter Activity T-tubule Negative Regulation Of Peptide Secretion Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Monoatomic Ion Transport Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Hormone Secretion TMEM240-body Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Negative Regulation Of Protein Secretion Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Potassium Channel Activity Regulation Of Protein Transport Transmembrane Transport Relaxation Of Skeletal Muscle Sarcolemma Regulation Of Establishment Of Protein Localization Regulation Of System Process	Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Presynaptic Active Zone Membrane Response To ATP Determination Of Adult Lifespan Potassium Ion Import Across Plasma Membrane Response To Ischemia Cardiac Muscle Tissue Development Atrioventricular Node Cell Differentiation Myosin Head/neck Binding Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Inorganic Cation Import Across Plasma Membrane Neurotransmitter Transport Protein Localization To Extracellular Region Potassium Ion-transporting ATPase Complex Synaptic Assembly At Neuromuscular Junction Striated Muscle Tissue Development Cardiac Pacemaker Cell Differentiation Action Potential Establishment Of Protein Localization To Extracellular Region Protein Secretion Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Glutamate Secretion, Neurotransmission Glucose Metabolic Process Lactate Dehydrogenase Activity Glucose Catabolic Process To Lactate Via Pyruvate Asymmetric Neuroblast Division Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Transmembrane Transporter Binding Somatic Muscle Development Import Across Plasma Membrane Potassium Ion Transmembrane Transport Import Into Cell Response To Purine-containing Compound Muscle Tissue Development L-lactate Dehydrogenase (NAD+) Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Calcium-mediated Signaling
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