KCNJ4 and GNGT2

Number of citations of the paper that reports this interaction (PMID 8943291)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KCNJ4	GNGT2
Gene Name		potassium channel, inwardly rectifying subfamily J, member 4	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Postsynaptic Membrane	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	GTPase Activity Signal Transducer Activity
	Biological Process	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport	G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Phototransduction Metabolic Process
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		10 interactors: CASK DLG1 DLG2 DLG4 GNGT2 IL16 KCNJ2 LIN7B PRKCD SNTA1	2 interactors: GNB4 KCNJ4
Entrez ID		3761	2793
HPRD ID		02738	06792
Ensembl ID		ENSG00000168135	ENSG00000167083
Uniprot IDs		P48050 Q58F07	O14610
PDB IDs		3GJ9
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Positive Regulation Of Ion Transport Receptor Clustering Synaptic Transmission Maintenance Of Apical/basal Cell Polarity Regulation Of Membrane Potential Maintenance Of Cell Polarity Protein Localization To Membrane Regulation Of Actin Filament-based Process Response To External Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Repolarization Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Muscle System Process Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Membrane Organization Regulation Of Potassium Ion Transport Negative Regulation Of Wound Healing Regulation Of Sodium Ion Transport Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Ion Transmembrane Transport Phosphorylation Organophosphate Metabolic Process Regulation Of Striated Muscle Contraction Action Potential Protein Stabilization Negative Regulation Of Homotypic Cell-cell Adhesion Relaxation Of Skeletal Muscle
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