KCNJ4 and GNGT2

Number of citations of the paper that reports this interaction (PubMedID 8943291)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KCNJ4	GNGT2
Description		potassium inwardly rectifying channel subfamily J member 4	G protein subunit gamma transducin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Synapse Postsynaptic Membrane	Heterotrimeric G-protein Complex Plasma Membrane Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	GTPase Activity G-protein Beta-subunit Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ranolazine Miconazole Carvedilol Dronedarone
Diseases
GWAS		Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)	Asthma ( 31619474) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		11 interacting genes: CASK DLG1 DLG2 DLG4 GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1	3 interacting genes: GNB4 KCNJ4 SRPK2
Entrez ID		3761	2793
HPRD ID		02738	06792
Ensembl ID		ENSG00000168135	ENSG00000167083
Uniprot IDs		P48050 Q58F07	O14610
PDB IDs		3GJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Metal Ion Transport GMP Kinase Activity GDP Metabolic Process Regulation Of Monoatomic Ion Transport Nucleoside Monophosphate Metabolic Process Neuromuscular Junction Postsynaptic Density Membrane GMP Metabolic Process Ionotropic Glutamate Receptor Binding Regulation Of Transport Plasma Membrane MPP7-DLG1-LIN7 Complex Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Cell-cell Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Basolateral Plasma Membrane Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex Nucleoside Diphosphate Metabolic Process Protein Localization To Cell Junction Regulation Of Monoatomic Cation Transmembrane Transport Juxtaparanode Region Of Axon Regulation Of Monoatomic Ion Transmembrane Transport Ribonucleotide Metabolic Process Cellular Response To Potassium Ion Ribose Phosphate Metabolic Process Kinase Binding Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Response To Potassium Ion Membrane Repolarization During Action Potential Nucleotide Metabolic Process Membrane Repolarization Establishment Or Maintenance Of Cell Polarity Regulation Of Membrane Potential Regulation Of Cardiac Muscle Cell Contraction Protein Kinase Binding Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Purine-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Monoatomic Ion Transport Synapse Adherens Junction Regulation Of Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction
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