KCNA2 and KCNAB2

Number of citations of the paper that reports this interaction (PubMedID 8636142)
0

Data Source:
HPRD (in vivo)

		KCNA2	KCNAB2
Description		potassium voltage-gated channel subfamily A member 2	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Axon Specific Granule Membrane Cell Projection Neuron Projection Juxtaparanode Region Of Axon Synapse Tertiary Granule Membrane Pinceau Fiber
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Transmembrane Transporter Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Monoatomic Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Localization To Cell Surface
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels Neutrophil degranulation
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	10 interacting genes: ATXN1 CD4 CEBPA KCNA2 LCOR NEDD4 NEDD4L SLC39A1 SLC39A2 SQSTM1
Entrez ID		3737	8514
HPRD ID		01443	03090
Ensembl ID		ENSG00000177301	ENSG00000069424
Uniprot IDs		P16389	B2R776 Q13303
PDB IDs			1ZSX 7EJ1 7EJ2 7WF3 7WF4
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Fat Cell Proliferation Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Metal Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Zinc Ion Transport Zinc Ion Transmembrane Transport Regulation Of Membrane Potential Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Macrophage Differentiation Positive Regulation Of Catabolic Process Receptor Metabolic Process Interleukin-16 Binding Regulation Of Biological Quality Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Monoatomic Cation Transmembrane Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Targeting To Vacuole Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Transcription By RNA Polymerase II Inorganic Ion Transmembrane Transport Energy Homeostasis Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Receptor Internalization Response To Methamphetamine Hydrochloride
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