KCNA2 and KCNAB1

Number of citations of the paper that reports this interaction (PubMedID 8636142)
0

Data Source:
HPRD (in vivo)

		KCNA2	KCNAB1
Description		potassium voltage-gated channel subfamily A member 2	potassium voltage-gated channel subfamily A regulatory beta subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Potassium Channel Complex Juxtaparanode Region Of Axon
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Carbonyl Reductase (NADPH) Activity Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Protein Domain Specific Binding Transmembrane Transporter Binding NADPH Binding Molecular Function Inhibitor Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Monoatomic Ion Transport Potassium Ion Transport Learning Or Memory Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Voltage-gated Potassium Channel Activity
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Age-related nuclear cataracts ( 24951543) Aging traits ( 17903295) Bevacizumab-induced hypertension ( 34616010) Coronary artery disease ( 26708285) Focal epilepsy (with hippocampal sclerosis) ( 30531953) Offspring birth weight ( 31043758)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	9 interacting genes: APP DLG1 FBXO7 KCNA2 NEDD4 NEDD4L SLC39A1 SLC39A2 SRPK1
Entrez ID		3737	7881
HPRD ID		01443	03089
Ensembl ID		ENSG00000177301	ENSG00000169282
Uniprot IDs		P16389	B7Z435 B7Z8E5 F8W6W4 Q14722 Q5MJQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transport Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Potassium Channel Inhibitor Activity Developmental Process Monoatomic Cation Transport Regulation Of Metal Ion Transport Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Transmembrane Transporter Binding Monoatomic Ion Transport Receptor Catabolic Process Metal Ion Transmembrane Transporter Activity Cell Junction Organization Negative Regulation Of Potassium Ion Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Zinc Ion Transport Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Leukocyte Activation Positive Regulation Of Protein Catabolic Process Plasma Membrane Neuromuscular Junction Development Regulation Of Sodium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Activation Regulation Of Cell Projection Organization Ubiquitin-protein Transferase Activity Receptor Metabolic Process Inorganic Ion Transmembrane Transport Protein Polyubiquitination Protein Monoubiquitination Monoatomic Ion Transmembrane Transport Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Regulation Of Response To Calcium Ion
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