KCNA2 and NEU1

Number of citations of the paper that reports this interaction (PubMedID 10896669)
0

Data Source:
BioGRID (enzymatic study)

		KCNA2	NEU1
Description		potassium voltage-gated channel subfamily A member 2	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process
Pathways		Voltage gated Potassium channels	Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Oseltamivir Celecoxib Acetylsalicylic acid
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	30 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC
Entrez ID		3737	4758
HPRD ID		01443	09751
Ensembl ID		ENSG00000177301	ENSG00000204386
Uniprot IDs		P16389	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy
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