KCNA2 and KCNA5

Number of citations of the paper that reports this interaction (PubMedID 12815189)
46

Data Source:
HPRD (in vivo)

		KCNA2	KCNA5
Description		potassium voltage-gated channel subfamily A member 2	potassium voltage-gated channel subfamily A member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Golgi Apparatus Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Membrane Z Disc Monoatomic Ion Channel Complex Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Action Potential Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Insulin Secretion Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Transmembrane Transport Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole
Diseases			Atrial fibrillation
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Femur bone mineral density x serum urate levels interaction ( 34046847) Longevity ( 30294719)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I
Entrez ID		3737	3741
HPRD ID		01443	08888
Ensembl ID		ENSG00000177301	ENSG00000130037
Uniprot IDs		P16389	P22460
PDB IDs
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Regulation Of Membrane Potential Cell Junction Anchoring Junction Neuromuscular Junction Glutamatergic Synapse Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Transport Juxtaparanode Region Of Axon Postsynaptic Density Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Angiotensin-activated Signaling Pathway Cell Adhesion Focal Adhesion Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Potassium Ion Transport Cellular Component Assembly Plasma Membrane Protein Localization To Postsynaptic Membrane Adherens Junction Protein Localization To Postsynapse Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transport Cell-substrate Junction Assembly Regulation Of Vesicle-mediated Transport Cell-substrate Junction Organization Regulation Of System Process Regulation Of Biological Quality Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Localization To Cell Periphery Receptor Localization To Synapse Regulation Of Cell Morphogenesis Receptor Clustering Regulation Of Blood Circulation Cell Junction Assembly Regulation Of Monoatomic Cation Transmembrane Transport Actin Filament Uncapping Protein Localization To Synapse P2Y1 Nucleotide Receptor Binding SUMO Conjugating Enzyme Activity Regulation Of Monoatomic Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Epidermal Growth Factor Receptor Signaling Pathway Synaptic Membrane Regulation Of Multicellular Organismal Process Cytoskeletal Protein Binding Protein Localization To Membrane
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