KCNA3 and BAX

Number of citations of the paper that reports this interaction (PubMedID 18818304)
32

Data Source:
HPRD (in vivo)

		KCNA3	BAX
Description		potassium voltage-gated channel subfamily A member 3	BCL2 associated X, apoptosis regulator
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Pore Complex Extracellular Exosome Cell Periphery Bcl-2 Family Protein Complex BAX Complex BAK Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding	Protein Binding Lipid Binding Channel Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein-folding Chaperone Binding BH3 Domain Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport	Ovarian Follicle Development Neuron Migration Leukocyte Homeostasis T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process DNA Damage Response Mitochondrion Organization Germ Cell Development Spermatogenesis Nervous System Development Sex Differentiation Mitochondrial Fusion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Response To Wounding Response To Toxic Substance Response To Salt Stress Post-embryonic Development Response To Ionizing Radiation Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Mitochondrial Membrane Potential Hypothalamus Development Cerebral Cortex Development Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Cellular Response To Stress Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Developmental Process Protein Insertion Into Mitochondrial Membrane Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Supramolecular Fiber Organization Cellular Response To Virus Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Positive Regulation Of Reproductive Process Positive Regulation Of Motor Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Voltage gated Potassium channels	Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX Pyroptosis TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor
Drugs		Enflurane Clofazimine Promethazine Miconazole Dalfampridine	TAK-901
Diseases			Colorectal cancer
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464)	Asthma ( 27611488) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BAX CAV1 CD3D DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2	30 interacting genes: ANP32B BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID ERN1 FBXL20 HSF2BP KCNA3 LEF1 MAP2K1 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 TRIM17 UHRF2 USP12 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		3738	581
HPRD ID		15937	02498
Ensembl ID		ENSG00000177272	ENSG00000087088
Uniprot IDs		P22001	I6LPK7 Q07812 Q5ZPJ0 Q5ZPJ1
PDB IDs		4BGC 7EJ1 7EJ2 7SSV 7SSX 7SSY 7SSZ 8DFL	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII 5W5X 5W5Z 5W60 5W61 6EB6 6L8V 6L95 6TRR 6XY6 7ADT 8G1T 8SPE 8SPF 8SPZ 8SRX 8SRY 8SVK
Enriched GO Terms of Interacting Partners?		Juxtaparanode Region Of Axon Regulation Of Membrane Potential Endoplasmic Reticulum Voltage-gated Potassium Channel Complex Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Epithelial Cell Proliferation Cellular Response To Topologically Incorrect Protein Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Metal Ion Transport Signal Transduction Regulation Of Transport Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Monoatomic Ion Transport Membrane Raft Organization Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Cell Action Potential Protein Localization To Postsynaptic Membrane Membrane Repolarization During Action Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Membrane Repolarization Neuronal Action Potential Axon Initial Segment Delayed Rectifier Potassium Channel Activity Localization Within Membrane Endothelial Cell Proliferation Cell Junction Positive Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Regulation Of System Process Protein-macromolecule Adaptor Activity Regulation Of Calcium Ion Transport Protein Localization To Cell Periphery Metal Ion Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Muscle System Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Immune System Process T Cell Homeostatic Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport BAX Complex Cell Surface Receptor Signaling Pathway Release Of Matrix Enzymes From Mitochondria	Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death DNA Damage Response Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Channel Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Cellular Response To Stress Mitochondrion Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Organelle Organization Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Autophagy Mitochondrial Membrane
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