CD226 and PVR

Number of citations of the paper that reports this interaction (PMID 12913096)
84

Data Source:
HPRD (in vitro)

		CD226	PVR
Gene Name		CD226 molecule	poliovirus receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Receptor Activity Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Viral Process Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697) Type 1 diabetes ( 17554260) Type 1 diabetes autoantibodies ( 21829393)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		4 interactors: FYN ITGB2 PVR PVRL2	18 interactors: AP1M2 CD226 CD96 DYNLT1 DYNLT3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NOTCH2NL PLA2G3 PVRL1 PVRL3 SLC30A2 TIGIT TNFRSF12A VTN WNK1
Entrez ID		10666	5817
HPRD ID		09252	01434
Ensembl ID		ENSG00000150637	ENSG00000073008
Uniprot IDs		J3QR77 Q15762	P15151
PDB IDs			1DGI 1NN8 3EPC 3EPD 3EPF 3UDW 3URO 4FQP
Enriched GO Terms of Interacting Partners?		Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response Positive Regulation Of Immune Response To Tumor Cell Activated T Cell Proliferation Positive Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Locomotion Regulation Of Immune System Process Viral Entry Into Host Cell Entry Into Host Cell T Cell Proliferation Response To External Stimulus Single Organismal Cell-cell Adhesion Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Proliferation Interaction With Host Mononuclear Cell Proliferation Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Proliferation Coreceptor-mediated Virion Attachment To Host Cell Cell Migration Cell Motility Positive Regulation Of Adaptive Immune Response Regulation Of Cell Shape Sperm Mitochondrion Organization Viral Life Cycle Regulation Of Adaptive Immune Response Cell Junction Assembly Cell-cell Junction Organization Fusion Of Virus Membrane With Host Plasma Membrane Leukocyte Migration Response To Virus T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Cell Adhesion Lens Morphogenesis In Camera-type Eye Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Immune System Process Positive Regulation Of Sequestering Of Zinc Ion Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Adherens Junction Organization Lens Development In Camera-type Eye Anatomical Structure Morphogenesis Cell Differentiation Interaction With Host Organelle Localization Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Wound Healing Camera-type Eye Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Intracellular Transport Of Viral Protein In Host Cell Transport Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Viral Process Eye Morphogenesis Retina Development In Camera-type Eye Enamel Mineralization Positive Regulation Of Immune Response To Tumor Cell Immune Response Viral Life Cycle Developmental Process Immune System Process Cell Junction Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Sperm Axoneme Assembly Tooth Mineralization Cell-cell Junction Organization Cell-substrate Adhesion Positive Regulation Of Systemic Arterial Blood Pressure Lipoxygenase Pathway Desmosome Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Mast Cell Activation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Phosphatidylglycerol Acyl-chain Remodeling Acrosome Assembly Amelogenesis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud ?		1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr	advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening
Tagcloud (Difference) ?		1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr	advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening
Tagcloud (Intersection) ?