CD226 and PVRL2

Number of citations of the paper that reports this interaction (PMID 12913096)
84

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CD226	PVRL2
Gene Name		CD226 molecule	poliovirus receptor-related 2 (herpesvirus entry mediator B)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Response To Virus Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697) Type 1 diabetes ( 17554260) Type 1 diabetes autoantibodies ( 21829393)	Age-related macular degeneration ( 23326517) Alzheimer's disease ( 18823527 22159054) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23419831) HDL cholesterol ( 21909109) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		4 interactors: FYN ITGB2 PVR PVRL2	20 interactors: ATP5J2 CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI MLLT4 NOTCH2NL PICK1 PVRL3 PVRL4 SIAH1 TIGIT TNFRSF12A USP53
Entrez ID		10666	5819
HPRD ID		09252	02879
Ensembl ID		ENSG00000150637	ENSG00000130202
Uniprot IDs		J3QR77 Q15762	Q92692
PDB IDs			3R0N 4DFH 4DFI 4HZA
Enriched GO Terms of Interacting Partners?		Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response Positive Regulation Of Immune Response To Tumor Cell Activated T Cell Proliferation Positive Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Locomotion Regulation Of Immune System Process Viral Entry Into Host Cell Entry Into Host Cell T Cell Proliferation Response To External Stimulus Single Organismal Cell-cell Adhesion Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Proliferation Interaction With Host Mononuclear Cell Proliferation Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Proliferation Coreceptor-mediated Virion Attachment To Host Cell Cell Migration Cell Motility Positive Regulation Of Adaptive Immune Response Regulation Of Cell Shape Sperm Mitochondrion Organization Viral Life Cycle Regulation Of Adaptive Immune Response Cell Junction Assembly Cell-cell Junction Organization Fusion Of Virus Membrane With Host Plasma Membrane Leukocyte Migration Response To Virus T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization
Tagcloud ?		1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr	adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?		1alpha activating atf6 attenuated cd112 cd155 contributed cytotoxicity decreasing degradation demonstrating erad evasion facilitated hcc hepatocellular hrd1 immunity inositol ire1alpha ligands meaningful nk requiring signals transduces treating unfolded upr	adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?