ITGA9 and GPX1

Data Source: HiPPIP (Novel)

		ITGA9	GPX1
Name		integrin subunit alpha 9	glutathione peroxidase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Membrane Integrin Alpha9-beta1 Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body
	Molecular Function	Protein Binding Signaling Receptor Activity Metal Ion Binding Integrin Binding Involved In Cell-matrix Adhesion	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Neutrophil Chemotaxis Negative Regulation Of Vasoconstriction Cell-cell Adhesion	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Apoptotic Process Response To Oxidative Stress Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Wounding Response To Toxic Substance UV Protection Response To Hormone Response To Glucose Response To Selenium Ion Response To Gamma Radiation Myotube Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Response To Estradiol Response To Lipopolysaccharide Response To Hydroperoxide Response To Vitamin E Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Epigenetic Regulation Of Gene Expression Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Myoblast Differentiation Cell Redox Homeostasis Fibroblast Proliferation Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Response To Folic Acid Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization
Pathways		Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species
Drugs		None	Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Anti-human herpes virus 6 IE1A IgG seropositivity ( 33204752 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mortality in sepsis ( 27639821 ) Nasopharyngeal carcinoma ( 19478819 ) Phospholipid levels (plasma) ( 22359512 ) Platelet count ( 32888494 ) PR interval ( 23139255 ) Pulse pressure ( 30224653 30578418 ) Response to antidepressants (symptom improvement) ( 29160301 ) Systolic blood pressure ( 30578418 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 21102463 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 23128233 28067908 ) Intelligence (MTAG) ( 29326435 ) Mood instability ( 31168069 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 25082827 )
Novel Interactors		1 novel interactors: GPX1	10 novel interactors: ACKR2 CAMP CISH EBNA1BP2 IDH2 ITGA9 MLH1 MST1R RHOA UQCRC1
Interacting Genes		6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD	6 interacting genes: ABL1 ABL2 CFTR FAM9B MAPK6 SELENBP1
Entrez ID		3680	2876
HPRD ID		04910	11749
Ensembl ID		ENSG00000144668	ENSG00000233276
Uniprot IDs		Q13797 Q8N6H6	A0A2R8Y6B6 P07203 Q7L4Q3
PDB IDs		Not available	2F8A
GO Terms Enriched among Interactors		Angiogenesis Endothelial Cell Migration Regulation Of Collateral Sprouting Enzyme-linked Receptor Protein Signaling Pathway Myoblast Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Fibroblast Proliferation Protein Tyrosine Kinase Binding Axon Extension Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Growth Muscle Cell Differentiation Striated Muscle Cell Differentiation Response To Vitamin Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Neuron Projection Extension Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Transforming Growth Factor Beta Receptor Signaling Pathway Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Regulation Of Neurogenesis Regulation Of Nervous System Development Integrin Alpha9-beta1 Complex Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Neuron Apoptotic Process Regulation Of Cellular Component Organization Developmental Cell Growth Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Positive Regulation Of Neuron Maturation Diamine N-acetyltransferase Activity Regulation Of Estradiol Secretion Growth Factor Activity	Positive Regulation Of T Cell Migration Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Enzyme Binding Regulation Of Vasoconstriction Regulation Of Lymphocyte Migration Enzyme Activator Activity Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Migration Odontogenesis Regulation Of Modification Of Synaptic Structure Positive Regulation Of Lymphocyte Activation Regulation Of Establishment Of Cell Polarity Actin Monomer Binding Protein Tyrosine Kinase Activity Synaptonemal Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Osteoblast Proliferation Mismatch Repair Cell-substrate Adhesion Regulation Of Tube Size Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Vasoconstriction Positive Regulation Of Cell Activation Nucleotide Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Lipopolysaccharide Response To Lipid Magnesium Ion Binding Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Prostaglandin Production Involved In Inflammatory Response Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment