AQP9 and SERINC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP9	SERINC1
Description		aquaporin 9	serine incorporator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Channel Activity Hydrogen Peroxide Channel Activity	Protein Binding Acetyltransferase Activator Activity Protein-macromolecule Adaptor Activity
	Biological Process	Water Transport Purine Nucleobase Transport Glycerol Transmembrane Transport Amine Transport Pyrimidine Nucleobase Transport Transmembrane Transport Cellular Response To CAMP Detoxification Of Arsenic-containing Substance Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transport	Lipid Metabolic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Membrane Biogenesis
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins	Serine metabolism
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Plateletcrit ( 27863252 32888494)
Interacting Genes		25 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 DVL2 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109	9 interacting genes: AQP9 CREB3 CYP39A1 FFAR3 GPR42 GPX8 MAK PAX8 ZMYND10
Entrez ID		366	57515
HPRD ID		04223	15480
Ensembl ID		ENSG00000103569	ENSG00000111897
Uniprot IDs		H0YK62 O43315	Q9NRX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Regulation Of Hormone Metabolic Process Negative Regulation Of Non-motile Cilium Assembly Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Regulation Of Thyroid-stimulating Hormone Secretion Metanephric Comma-shaped Body Morphogenesis Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Deacetylase Activity Steroid 7-alpha-hydroxylase Activity Oxysterol 7-alpha-hydroxylase Activity 24S-hydroxycholesterol 7-alpha-hydroxylase Activity Positive Regulation Of Motile Cilium Assembly Regulation Of Cilium Assembly Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Positive Regulation Of Thyroid Hormone Generation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Intracellular Membrane-bounded Organelle Glycerol Channel Activity Metanephric Tubule Formation Negative Regulation Of Somatic Stem Cell Population Maintenance Release From Viral Latency Urea Transmembrane Transporter Activity Pyrimidine Nucleobase Transport Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis S-shaped Body Morphogenesis CCR1 Chemokine Receptor Binding Purine Nucleobase Transmembrane Transport Glycerol Transmembrane Transport Pronephros Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Otic Vesicle Development Cholesterol Catabolic Process
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