AQP9 and TMEM109

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AQP9	TMEM109
Name		aquaporin 9	transmembrane protein 109
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Extracellular Exosome
	Molecular Function	Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Channel Activity Hydrogen Peroxide Channel Activity	Protein Binding Voltage-gated Monoatomic Cation Channel Activity
	Biological Process	Water Transport Purine Nucleobase Transport Glycerol Transmembrane Transport Amine Transport Pyrimidine Nucleobase Transport Transmembrane Transport Cellular Response To CAMP Detoxification Of Arsenic-containing Substance Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transport	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Monoatomic Cation Transmembrane Transport
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Aspartate aminotransferase levels ( 33547301 ) Glycine levels ( 30837465 ) HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels in HIV infection ( 33109212 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Ischemic stroke ( 26089329 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 29403010 ) Metabolite levels ( 23823483 22916037 ) Serum alkaline phosphatase levels ( 33547301 ) Small cell lung carcinoma ( 28604730 ) Stroke ( 26089329 ) Triglyceride levels ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 DVL2 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109	16 interacting genes: AQP2 AQP9 ERGIC3 GOLM1 GPX8 LMNA MGST3 MTIF3 PDZK1IP1 RNF170 SAR1A SLC18A2 SPINT1 STOM TMEM52B TMEM80
Entrez ID		366	79073
HPRD ID		04223	14687
Ensembl ID		ENSG00000103569	ENSG00000110108
Uniprot IDs		H0YK62 O43315	Q9BVC6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane	Polyol Transmembrane Transport Glycerol Transmembrane Transport Amine Transport Water Channel Activity Membrane Glutathione Peroxidase Activity Water Transport Organic Hydroxy Compound Transport Fluid Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Channel Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Transport Vesicle Membrane Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Amino Acid Sensor Activity Mitochondrial Translational Initiation Cellular Response To Mercury Ion Cellular Response To Water Deprivation Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Cellular Oxidant Detoxification Histamine Uptake Serotonin:sodium:chloride Symporter Activity