AQP9 and EMC6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP9	EMC6
Description		aquaporin 9	ER membrane protein complex subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex Omegasome Membrane
	Molecular Function	Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Protein Binding Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Channel Activity Hydrogen Peroxide Channel Activity	Protein Binding Membrane Insertase Activity
	Biological Process	Water Transport Purine Nucleobase Transport Glycerol Transmembrane Transport Amine Transport Pyrimidine Nucleobase Transport Transmembrane Transport Cellular Response To CAMP Detoxification Of Arsenic-containing Substance Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Purine Nucleobase Transmembrane Transport	Autophagosome Assembly Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		25 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 DVL2 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109	21 interacting genes: AQP6 AQP9 CD79A CREB3 EBP ELOVL4 ERGIC3 FAM209A FFAR2 MMD MUC1 PDZK1IP1 SLC10A1 SLC10A6 SLC35H1 SLC39A2 SLC71A2 SLC7A1 TLCD4 TMEM14B TMEM237
Entrez ID		366	83460
HPRD ID		04223	14529
Ensembl ID		ENSG00000103569	ENSG00000127774
Uniprot IDs		H0YK62 O43315	Q9BV81
PDB IDs			6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Bile Acid:sodium Symporter Activity Transmembrane Transport Water Channel Activity Bile Acid And Bile Salt Transport Nitrate Transmembrane Transporter Activity One-carbon Compound Transport Fluid Transport Water Transport Channel Activity Organic Hydroxy Compound Transport Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Organic Anion Transport Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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