HMGCR and ARHGAP1

Number of citations of the paper that reports this interaction (PMID 14697242)
13

Data Source:
HPRD (two hybrid)

		HMGCR	ARHGAP1
Gene Name		3-hydroxy-3-methylglutaryl-CoA reductase	Rho GTPase activating protein 1
Image
Gene Ontology Annotations	Cellular Component	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Ruffle Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity Protein Homodimerization Activity Coenzyme Binding NADPH Binding	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Rac GTPase Activator Activity
	Biological Process	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Myoblast Differentiation Response To Ethanol Negative Regulation Of Vasodilation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Protein Tetramerization Oxidation-reduction Process Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs		NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Adenosine-5\'-Diphosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-Hydroxy-3-Methyl-Glutaric Acid 1,4-Dithiothreitol Mevastatin 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID Pitavastatin
Diseases
GWAS		Body mass index ( 20935630) Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 19060911 20686565) Metabolite levels ( 21909109) Quantitative traits ( 19197348)	Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		4 interactors: ARHGAP1 INSIG1 PRKACA STARD13	21 interactors: BAI2 BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS
Entrez ID		3156	392
HPRD ID		00836	04108
Ensembl ID		ENSG00000113161	ENSG00000175220
Uniprot IDs		P04035	Q07960
PDB IDs		1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB	1AM4 1GRN 1OW3 1RGP 1TX4 2NGR
Enriched GO Terms of Interacting Partners?		Triglyceride Metabolic Process Neutral Lipid Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Catalytic Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Glycerolipid Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus SREBP Signaling Pathway Cell Communication By Electrical Coupling Signal Transduction Activation Of Protein Kinase A Activity Response To Sterol Depletion Regulation Of Cellular Ketone Metabolic Process Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Skeletal System Development Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Wounding Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Axon Guidance Phagocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Costimulation Axonogenesis Movement Of Cell Or Subcellular Component Innate Immune Response Platelet Activation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Neurotrophin Signaling Pathway Regulation Of Protein Transport Neuron Projection Morphogenesis Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Phosphatidylinositol 3-kinase Activity Programmed Cell Death Cell Morphogenesis Involved In Differentiation Cell Death Death Regulation Of Lipid Kinase Activity Regulation Of Protein Localization Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Generation Of Neurons Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Regulation Of Immune Response Neurogenesis Locomotion
Tagcloud ?		7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr	al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr	al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?