HMGCR and STARD13

Number of citations of the paper that reports this interaction (PMID 14697242)
13

Data Source:
HPRD (in vivo, two hybrid)

		HMGCR	STARD13
Gene Name		3-hydroxy-3-methylglutaryl-CoA reductase	StAR-related lipid transfer (START) domain containing 13
Image
Gene Ontology Annotations	Cellular Component	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Lipid Particle Cytosol Mitochondrial Membrane
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity Protein Homodimerization Activity Coenzyme Binding NADPH Binding	GTPase Activator Activity Protein Binding Lipid Binding
	Biological Process	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Myoblast Differentiation Response To Ethanol Negative Regulation Of Vasodilation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Protein Tetramerization Oxidation-reduction Process Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs		NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Adenosine-5\'-Diphosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-Hydroxy-3-Methyl-Glutaric Acid 1,4-Dithiothreitol Mevastatin 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID Pitavastatin
Diseases
GWAS		Body mass index ( 20935630) Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 19060911 20686565) Metabolite levels ( 21909109) Quantitative traits ( 19197348)	Body mass index (asthmatics) ( 23517042) Intracranial aneurysm ( 20364137)
Protein-Protein Interactions		4 interactors: ARHGAP1 INSIG1 PRKACA STARD13	12 interactors: BAI2 EPB41L1 HMGCR HSP90AA1 HSP90AB1 ITPR1 KIF1B SMAD1 SMARCD3 TAX1BP1 TUBA1A TUBA4A
Entrez ID		3156	90627
HPRD ID		00836	11607
Ensembl ID		ENSG00000113161	ENSG00000133121
Uniprot IDs		P04035	B2R789 B3KRK6 Q9Y3M8
PDB IDs		1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB	2H80 2JW2 2PSO
Enriched GO Terms of Interacting Partners?		Triglyceride Metabolic Process Neutral Lipid Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Catalytic Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Glycerolipid Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus SREBP Signaling Pathway Cell Communication By Electrical Coupling Signal Transduction Activation Of Protein Kinase A Activity Response To Sterol Depletion Regulation Of Cellular Ketone Metabolic Process Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Skeletal System Development Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway	Cellular Response To Interleukin-4 Response To Interleukin-4 Protein Folding Cellular Protein Complex Assembly G2/M Transition Of Mitotic Cell Cycle Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Organic Substance Protein Complex Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Macromolecular Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cell Cycle Phase Transition Phagocytosis Cell Cycle Phase Transition Regulation Of Muscle Cell Apoptotic Process Fc Receptor Signaling Pathway Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway 'de Novo' Posttranslational Protein Folding Regulation Of Nitric Oxide Biosynthetic Process 'de Novo' Protein Folding Vesicle-mediated Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Heat Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Polymerization Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Heat Cellular Component Assembly Response To Abiotic Stimulus Voluntary Musculoskeletal Movement Cardiac Right Ventricle Formation Protein Import Into Mitochondrial Outer Membrane Establishment Of Localization In Cell Response To Unfolded Protein Cytoskeleton-dependent Intracellular Transport Regulation Of Protein Binding Cellular Response To Cytokine Stimulus Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr	aberrant abilities addressed appearing bioinformatics certified clinicopathological colony colorectal corresponding crc curve distant healing indicator invasion kaplan luciferase lymphatic meier metastasis mimics mir nats poorer tnm untranslated utr wound
Tagcloud (Difference) ?		7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6	aberrant abilities addressed appearing bioinformatics certified clinicopathological colony colorectal corresponding crc curve distant healing indicator invasion kaplan luciferase lymphatic meier metastasis mimics mir nats poorer tnm untranslated wound
Tagcloud (Intersection) ?		utr