HMGCR and STARD13

Number of citations of the paper that reports this interaction (PubMedID 14697242)
0

Data Source:
HPRD (in vivo, two hybrid)

		HMGCR	STARD13
Description		3-hydroxy-3-methylglutaryl-CoA reductase	StAR related lipid transfer domain containing 13
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GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Mitochondrion Lipid Droplet Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor GTPase Regulator Activity NADP Binding NADPH Binding Coenzyme A Binding	GTPase Activator Activity Protein Binding Lipid Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Visual Learning Coenzyme A Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Long-term Synaptic Potentiation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Amyloid-beta Clearance	Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Rho Protein Signal Transduction Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tube Lumen Extension Negative Regulation Of Sprouting Angiogenesis
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs		NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 20935630) Cholesterol ( 31902109) Cholesterol, total ( 19060911 28270201 20686565 26582766 25961943 24097068) Coronary artery disease ( 33020668) LDL cholesterol ( 18802019 26582766 25961943 24097068 18193044 20864672 20686565 19060906 19060911) LDL cholesterol levels ( 32203549 28334899 31087446) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 29403010 32154731 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Quantitative traits ( 19197348) Total cholesterol levels ( 31087446 30275531 28334899 33339817) Type 2 diabetes ( 32499647)	Body mass index in asthmatics ( 23517042) Colorectal cancer or advanced adenoma ( 30510241) Diverticular disease ( 30177863) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Intracranial aneurysm ( 20364137) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Mild age-related type 2 diabetes ( 34737425) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13 TMUB1	12 interacting genes: ADGRB2 EPB41L1 HMGCR HSP90AA1 HSP90AB1 ITPR1 KIF1B SMAD1 SMARCD3 TAX1BP1 TUBA1A TUBA4A
Entrez ID		3156	90627
HPRD ID		00836	11607
Ensembl ID		ENSG00000113161	ENSG00000133121
Uniprot IDs		P04035	B2R789 B3KRK6 H3BRG5 Q9Y3M8
PDB IDs		1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB 8PKN 8S6B	2H80 2JW2 2PSO
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Intracellular Transport Regulation Of Steroid Biosynthetic Process Regulation Of Cellular Localization Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Endothelial Tube Lumen Extension Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Endocytic Recycling Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Cellular Response To Peptide Hormone Stimulus Regulation Of Lipid Biosynthetic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Negative Regulation Of SREBP Signaling Pathway Sorting Endosome CAMP-dependent Protein Kinase Activity Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Intracellular Transport GTPase Activator Activity Protein Transport Regulation Of Lipid Metabolic Process Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Cranial Suture Morphogenesis Response To Sterol Depletion Negative Regulation Of Protein Exit From Endoplasmic Reticulum Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Small Molecule Metabolic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Cellular Response To Sterol Depletion CAMP-dependent Protein Kinase Complex	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Apoptotic Process Protein Folding Chaperone Complex Cell Death Programmed Cell Death ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Visual Learning Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Nucleotide Binding CTP Binding DATP Binding Cellular Response To Heat Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Nuclear Inner Membrane Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Visual Behavior Regulation Of Nitric Oxide Metabolic Process Ubiquitin Protein Ligase Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Homomeric SMAD Protein Complex Protein Localization To Phagocytic Vesicle Protein-containing Complex Response To Unfolded Protein Response To Heat Microtubule Organelle Transport Along Microtubule Regulation Of Protein Catabolic Process Associative Learning DNA Biosynthetic Process Rho GDP-dissociation Inhibitor Binding GTP Binding ATP Hydrolysis Activity
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