HMGCR

Gene Name		3-hydroxy-3-methylglutaryl-CoA reductase
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Gene Ontology Annotations	Cellular Component	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity Protein Homodimerization Activity Coenzyme Binding NADPH Binding
	Biological Process	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Myoblast Differentiation Response To Ethanol Negative Regulation Of Vasodilation Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Protein Tetramerization Oxidation-reduction Process Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs		NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Adenosine-5\'-Diphosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-Hydroxy-3-Methyl-Glutaric Acid 1,4-Dithiothreitol Mevastatin 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID Pitavastatin
Diseases
GWAS		Body mass index ( 20935630) Cholesterol, total ( 19060911 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 19060911 20686565) Metabolite levels ( 21909109) Quantitative traits ( 19197348)
Protein-protein Interactions		4 interactors: ARHGAP1 INSIG1 PRKACA STARD13
Entrez ID		3156
HPRD ID		00836
Ensembl ID		ENSG00000113161
Uniprot IDs		P04035
PDB IDs		1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
Enriched GO Terms of Interacting Partners?		Triglyceride Metabolic Process Neutral Lipid Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Catalytic Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Glycerolipid Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus SREBP Signaling Pathway Cell Communication By Electrical Coupling Signal Transduction Activation Of Protein Kinase A Activity Response To Sterol Depletion Regulation Of Cellular Ketone Metabolic Process Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Skeletal System Development Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Tagcloud ?		7b alteration alters bh3 biosynthesis cholesterol chop clues downregulation ebp emerged foxj2 h460 hmgcs1 idi1 inverse let lna mirna mirnas mirnome nac nci played respective scavenger silencing stat6 utr