DPPA3 and DEPDC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPPA3	DEPDC5
Description		developmental pluripotency associated 3	DEP domain containing 5, GATOR1 subcomplex subunit
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GO Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleus Cytoplasm	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	Protein Binding Histone H3K9me2/3 Reader Activity	GTPase Activator Activity Protein Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Chromatin Organization Epigenetic Programing Of Female Pronucleus	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Chromatin modifications during the maternal to zygotic transition (MZT)	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Borderline personality disorder ( 28632202) White matter hyperintensities in ischemic stroke ( 26674333)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)
Interacting Genes		15 interacting genes: CFTR DEPDC5 DYNLL1 DYNLL2 HAUS7 IPO5 KRT27 KRT76 NUP62 PLEKHG4 SERTAD3 SYCE1L TFIP11 TRIB3 ZNF618	11 interacting genes: CCT3 DPPA3 KLHL22 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2
Entrez ID		359787	9681
HPRD ID		16331	16795
Ensembl ID		ENSG00000187569	ENSG00000100150
Uniprot IDs		Q6W0C5	A0A2R8Y5T1 A0A2R8Y6H3 A0A2R8Y6V4 H0Y770 O75140
PDB IDs		8WMS 8XV7 8XV8	6CES 6CET 7T3A 7T3B 7T3C 8FW5
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Autophagy Negative Regulation Of Mitotic Nuclear Division Gtr1-Gtr2 GTPase Complex Regulation Of Mitotic Sister Chromatid Separation Cellular Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cellular Response To Amino Acid Stimulus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of TORC1 Signaling Regulation Of Sister Chromatid Segregation Response To Amino Acid Regulation Of Mitotic Nuclear Division Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of TOR Signaling Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cellular Response To Starvation Regulation Of Mitotic Cell Cycle Mitotic Sister Chromatid Segregation GTPase Binding Negative Regulation Of Mitotic Cell Cycle Sister Chromatid Segregation Response To Starvation Negative Regulation Of Cell Cycle Phase Transition Protein Stabilization Nuclear Chromosome Segregation Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Guanyl Ribonucleotide Binding DNA Damage Response, Signal Transduction Resulting In Transcription Cytoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization
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