DPPA3 and HAUS7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPPA3	HAUS7
Description		developmental pluripotency associated 3	HAUS augmin like complex subunit 7
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GO Annotations	Cellular Component	Female Pronucleus Male Pronucleus Nucleus Cytoplasm	Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Ciliary Basal Body HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Histone H3K9me2/3 Reader Activity	Protein Binding Thioesterase Binding Microtubule Minus-end Binding
	Biological Process	Chromatin Organization Epigenetic Programing Of Female Pronucleus	Centrosome Cycle Regulation Of Microtubule Nucleation Microtubule Organizing Center Organization Spindle Assembly Cell Division
Pathways		Chromatin modifications during the maternal to zygotic transition (MZT)	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Borderline personality disorder ( 28632202) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		15 interacting genes: CFTR DEPDC5 DYNLL1 DYNLL2 HAUS7 IPO5 KRT27 KRT76 NUP62 PLEKHG4 SERTAD3 SYCE1L TFIP11 TRIB3 ZNF618	4 interacting genes: ATF4 CSNK1E DPPA3 UCHL5
Entrez ID		359787	55559
HPRD ID		16331	18695
Ensembl ID		ENSG00000187569	ENSG00000213397
Uniprot IDs		Q6W0C5	Q99871
PDB IDs		8WMS 8XV7 8XV8	7SQK
Enriched GO Terms of Interacting Partners?			Circadian Regulation Of Gene Expression Lewy Body Core Response To Manganese-induced Endoplasmic Reticulum Stress ATF1-ATF4 Transcription Factor Complex L-asparagine Metabolic Process CHOP-ATF4 Complex Positive Regulation Of Sodium-dependent Phosphate Transport Circadian Rhythm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Programing Of Female Pronucleus GDF15-GFRAL Signaling Pathway ATF4-CREB1 Transcription Factor Complex Negative Regulation Of Translational Initiation In Response To Stress Asparagine Metabolic Process Regulation Of Sodium-dependent Phosphate Transport Regulation Of Proteasomal Protein Catabolic Process Rhythmic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process PERK-mediated Unfolded Protein Response HRI-mediated Signaling Cellular Response To Leucine Starvation Lens Fiber Cell Morphogenesis Regulation Of Phosphate Transport Mitochondrial Respirasome Assembly Response To Manganese Ion Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Cellular Response To Manganese Ion General Transcription Initiation Factor Binding Regulation Of Protein Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ino80 Complex Forebrain Morphogenesis Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Male Pronucleus Female Pronucleus Epigenetic Programming In The Zygotic Pronuclei Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Nuclear Periphery Positive Regulation Of Smooth Muscle Cell Apoptotic Process Proteasome Binding Regulation Of DNA Strand Elongation Histone H3K9me2/3 Reader Activity
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