IL12B and IL12A

Number of citations of the paper that reports this interaction (PMID 10899108)
25

Data Source:
HPRD (in vitro)

		IL12B	IL12A
Gene Name		interleukin 12B	interleukin 12A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Interleukin-12 Complex Interleukin-23 Complex	Extracellular Space Cytoplasm Interleukin-12 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein Homodimerization Activity Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Arrest Response To UV-B Positive Regulation Of Activation Of JAK2 Kinase Activity Cell Migration Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Sexual Reproduction Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cytokine Biosynthetic Process T-helper 1 Type Immune Response T-helper Cell Differentiation Interferon-gamma Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Alpha-D-Mannose
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Crohn's disease ( 18587394 17554261 20570966 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088) Psoriasis ( 20953188 20953190 19169254 19169255) Psoriatic arthritis ( 20953186) Response to taxane treatment (placlitaxel) ( 23006423) Ulcerative colitis ( 21297633)	Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Major depressive disorder ( 23377640) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		3 interactors: IL12A IL12RB1 IL12RB2	5 interactors: CD28 CXCL8 EBI3 IL12B WASF1
Entrez ID		3593	3592
HPRD ID		01194	01193
Ensembl ID		ENSG00000113302	ENSG00000168811
Uniprot IDs		P29460	E9PGR3 O60595 P29459
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR	1F45 3HMX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Production Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Interleukin-23-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Proliferation Positive Regulation Of Cell-cell Adhesion Interleukin-12-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Interleukin-12 Response To Molecule Of Bacterial Origin Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response To Tumor Cell Cytokine-mediated Signaling Pathway Regulation Of Memory T Cell Differentiation Regulation Of Cell Activation Response To Bacterium Response To Organic Substance Negative Regulation Of Interleukin-17 Production	Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cytokine Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion T-helper 1 Type Immune Response Cytokine Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Cell Activation Leukocyte Activation Regulation Of Viral Genome Replication Regulation Of Cytokine Production Regulation Of Defense Response To Virus Regulation Of Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Cell Activation Response To Cytokine Immune System Process Cytokine Production Regulation Of Protein Metabolic Process Cell Cycle Arrest Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Proliferation Interferon-gamma Biosynthetic Process Cellular Response To Lipopolysaccharide T Cell Differentiation Regulation Of Viral Process Cellular Response To Molecule Of Bacterial Origin
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Difference) ?		candidiasis cybb definition designation errors immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	dataset datasets discovery disequilibrium goldengate icc ifng ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Intersection) ?		allelic ifngr1 ifngr2