IL12B and IL12A

Number of citations: 53 (PubMedID 10899108)
Data Source: HPRD (in vitro)

		IL12B	IL12A
Name		interleukin 12B	interleukin 12A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Cell Surface Membrane Endosome Lumen Late Endosome Lumen Interleukin-12 Complex Interleukin-23 Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Cytokine Receptor Binding Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein-containing Complex Binding Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Response To UV-B Cell Migration Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway T-helper 1 Type Immune Response T-helper Cell Differentiation T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation T Cell Activation Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Oocyte Development Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein T-helper 1 Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tildrakizumab Risankizumab	None
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	None
GWAS		Ankylosing spondylitis ( 23749187 21743469 ) Blood protein levels ( 30072576 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 18587394 32581322 17554261 20570966 30500874 21102463 28067908 ) Cutaneous psoriasis ( 26626624 ) Inflammatory bowel disease ( 26278503 23128233 28067908 ) interleukin 12 receptor subunit beta-1 levels ( 25147954 ) Leprosy ( 25642632 32421744 ) Multiple sclerosis ( 22190364 21833088 ) Pediatric autoimmune diseases ( 26301688 ) Primary biliary cholangitis ( 26394269 ) Psoriasis ( 25854761 25903422 19169254 23143594 19169255 20953190 20953188 ) Psoriasis vulgaris ( 26626624 ) Psoriatic arthritis ( 26626624 20953186 ) Response to taxane treatment (paclitaxel) ( 23006423 ) Sarcoidosis ( 26051272 ) Serum sulfate level ( 27412988 ) Takayasu arteritis ( 23830517 33308445 ) Tuberculosis susceptibility in HIV infection ( 26942285 ) Ulcerative colitis ( 28067908 21297633 )	Autoimmune traits (pleiotropy) ( 30572963 ) Behcet's disease ( 25799145 27548383 23291587 ) Bipolar disorder ( 31043756 ) Celiac disease ( 18311140 25920553 22057235 20190752 ) Limited cutaneous systemic scleroderma ( 24387989 ) Major depressive disorder ( 23377640 ) Multiple sclerosis ( 21833088 24076602 19525953 ) Primary biliary cholangitis ( 28425483 28062665 19458352 26394269 21399635 20639880 ) Primary biliary cirrhosis ( 22961000 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 26502338 27399966 28714469 ) Systemic sclerosis ( 24387989 31672989 )
Interacting Genes		3 interacting genes: IL12A IL12RB1 IL12RB2	7 interacting genes: CD28 CXCL8 EBI3 IL12B S100A6 S100P WASF1
Entrez ID		3593	3592
HPRD ID		01194	01193
Ensembl ID		ENSG00000113302	ENSG00000168811
Uniprot IDs		P29460	O60595 P29459
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4 8XRP 8YI7	1F45 3HMX 8XRP 8YI7
GO Terms Enriched among Interactors		Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Differentiation T-helper Cell Differentiation T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Alpha-beta T Cell Differentiation T Cell Activation Involved In Immune Response Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Alpha-beta T Cell Activation Regulation Of Type II Interferon Production Lymphocyte Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response T Cell Differentiation Cell Activation Involved In Immune Response Lymphocyte Differentiation T Cell Activation Mononuclear Cell Differentiation Leukocyte Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Effector Process Cytokine-mediated Signaling Pathway Cytokine Binding Lymphocyte Activation Regulation Of T Cell Mediated Cytotoxicity Cytokine Receptor Activity Positive Regulation Of Cytokine Production Leukocyte Activation Coreceptor Activity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cell Activation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cytokine Production Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Population Proliferation Regulation Of Alpha-beta T Cell Activation Interleukin-12 Beta Subunit Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-27 Binding Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-12 Receptor Activity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-12 Complex	Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Lymphocyte Proliferation Regulation Of Alpha-beta T Cell Activation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Activation Regulation Of T Cell Proliferation Cell Activation Cytokine Activity Positive Regulation Of Interleukin-10 Production Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Humoral Immune Response Regulation Of Cell Population Proliferation Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Population Proliferation CD4-positive, Alpha-beta T Cell Activation Regulation Of Interleukin-10 Production Positive Regulation Of Immune System Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-12 Alpha Subunit Binding Regulation Of Viral Genome Replication Calcium-dependent Protein Binding Extracellular Region Regulation Of CD4-positive, Alpha-beta T Cell Activation Lymphocyte Activation Immune Response Positive Regulation Of Cell Adhesion Alpha-beta T Cell Activation Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Interleukin-8 Receptor Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains