IL12B

Gene Name		interleukin 12B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Interleukin-12 Complex Interleukin-23 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein Homodimerization Activity Interleukin-23 Receptor Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Arrest Response To UV-B Positive Regulation Of Activation Of JAK2 Kinase Activity Cell Migration Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Sexual Reproduction Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cytokine Biosynthetic Process T-helper 1 Type Immune Response T-helper Cell Differentiation Interferon-gamma Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Alpha-D-Mannose
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Crohn's disease ( 18587394 17554261 20570966 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088) Psoriasis ( 20953188 20953190 19169254 19169255) Psoriatic arthritis ( 20953186) Response to taxane treatment (placlitaxel) ( 23006423) Ulcerative colitis ( 21297633)
Protein-protein Interactions		3 interactors: IL12A IL12RB1 IL12RB2
Entrez ID		3593
HPRD ID		01194
Ensembl ID		ENSG00000113302
Uniprot IDs		P29460
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Production Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Interleukin-23-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Proliferation Positive Regulation Of Cell-cell Adhesion Interleukin-12-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Interleukin-12 Response To Molecule Of Bacterial Origin Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response To Tumor Cell Cytokine-mediated Signaling Pathway Regulation Of Memory T Cell Differentiation Regulation Of Cell Activation Response To Bacterium Response To Organic Substance Negative Regulation Of Interleukin-17 Production
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly