IL12B and IL12RB2

Number of citations of the paper that reports this interaction (PMID 11940489)
8

Data Source:
HPRD (in vivo)

		IL12B	IL12RB2
Gene Name		interleukin 12B	interleukin 12 receptor, beta 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Interleukin-12 Complex Interleukin-23 Complex	Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein Homodimerization Activity Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Receptor Activity Protein Kinase Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Arrest Response To UV-B Positive Regulation Of Activation Of JAK2 Kinase Activity Cell Migration Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Sexual Reproduction Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cytokine Biosynthetic Process T-helper 1 Type Immune Response T-helper Cell Differentiation Interferon-gamma Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production
Pathways
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Alpha-D-Mannose
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Crohn's disease ( 18587394 17554261 20570966 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088) Psoriasis ( 20953188 20953190 19169254 19169255) Psoriatic arthritis ( 20953186) Response to taxane treatment (placlitaxel) ( 23006423) Ulcerative colitis ( 21297633)	Behcet's disease ( 20622878 20622879) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		3 interactors: IL12A IL12RB1 IL12RB2	5 interactors: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3593	3595
HPRD ID		01194	03383
Ensembl ID		ENSG00000113302	ENSG00000081985
Uniprot IDs		P29460	B4DGA4 Q99665
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Production Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Interleukin-23-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Proliferation Positive Regulation Of Cell-cell Adhesion Interleukin-12-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Interleukin-12 Response To Molecule Of Bacterial Origin Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response To Tumor Cell Cytokine-mediated Signaling Pathway Regulation Of Memory T Cell Differentiation Regulation Of Cell Activation Response To Bacterium Response To Organic Substance Negative Regulation Of Interleukin-17 Production	Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Cytokine Stimulus Response To Interferon-gamma Response To Cytokine Interleukin-12-mediated Signaling Pathway JAK-STAT Cascade Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Organic Substance Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Response To Organic Substance Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?