SHROOM2 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 30726710)
43

Data Source:
BioGRID (unspecified method)

		SHROOM2	RPS6KA1
Description		shroom family member 2	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse
	Molecular Function	Actin Binding Protein Binding Beta-catenin Binding Ligand-gated Sodium Channel Activity Actin Filament Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Lens Morphogenesis In Camera-type Eye Actin Filament Organization Brain Development Eye Pigment Granule Organization Cell Migration Establishment Of Melanosome Localization Melanosome Organization Sodium Ion Transmembrane Transport Camera-type Eye Development Cellular Pigment Accumulation Ear Development Apical Protein Localization Camera-type Eye Morphogenesis Actin Filament Bundle Assembly	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Purvalanol A Fostamatinib
Diseases
GWAS		Colorectal cancer ( 22634755) Prostate cancer ( 23535732)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ACE2 RPS6KA1 TTC3 YWHAG	88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		357	6195
HPRD ID		02113	03402
Ensembl ID		ENSG00000146950	ENSG00000117676
Uniprot IDs		B7Z682 F5H3B6 Q13796	Q15418
PDB IDs		5F4Y 5F5P	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV
Enriched GO Terms of Interacting Partners?		Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Intracellular Signal Transduction TOR Signaling TORC1 Signaling Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Protein Kinase C Inhibitor Activity Entry Receptor-mediated Virion Attachment To Host Cell Protein Metabolic Process Viral Translation Viral Life Cycle Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Ribosomal Protein S6 Kinase Activity Protein Polyubiquitination Proteolysis Receptor-mediated Virion Attachment To Host Cell Tryptophan Transport Positive Regulation Of Gap Junction Assembly Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Angiotensin Maturation Protein Modification Process Positive Regulation Of Cell Activation Negative Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process Regulation Of Translation Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding Positive Regulation Of Immune Response To Tumor Cell Regulation Of Translation In Response To Stress Positive Regulation Of Amino Acid Transport	Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction
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